EPS003

CUDC 101

A potent inhibitor of HDACs and receptor tyrosine kinases

• 동의어(들): 7-[[4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yl]oxy]-N-hydroxyheptanamide, Heptanamide, 7-[[4-[(3-ethynylphenyl)amino]-7-methoxy-6-quinazolinyl]oxy]-N-hydroxy
• 실험식(Hill 표기법): C₂₄H₂₆N₄O₄
• CAS Number: 1012054-59-9
• Molecular Weight: 434.49
• MDL number: MFCD15528940
• UNSPSC 코드: 12352200
• NACRES: NA.41

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 색상: white
• solubility: DMSO: soluble
• 저장 온도: −20°C
• SMILES string: N(O)C(=O)CCCCCCOc1cc2c(ncnc2Nc3cc(ccc3)C#C)cc1OC
• InChI: 1S/C24H26N4O4/c1-3-17-9-8-10-18(13-17)27-24-19-14-22(21(31-2)15-20(19)25-16-26-24)32-12-7-5-4-6-11-23(29)28-30/h1,8-10,13-16,30H,4-7,11-12H2,2H3,(H,28,29)(H,25,26,27)
• InChI key: PLIVFNIUGLLCEK-UHFFFAOYSA-N

설명

일반 설명

A potent multitargeted inhibitor of histone deacetylase (HDAC) and the receptor kinases epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2), with IC50 values of 4.4, 2.4, and 15.7 nM, respectively.

Displays potent antiproliferative and proapoptotic activities against cultured and implanted tumor cells that are sensitive or resistant to several approved single-targeted drugs.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable