F6771

Fumagillin

from Aspergillus sp. (Aspergillus fumigatus), ≥90% (HPLC), powder, MetAP2 inhibitor

• 동의어(들): Fugillin
• 실험식(Hill 표기법): C₂₆H₃₄O₇
• CAS Number: 23110-15-8
• Molecular Weight: 458.54
• EC Number: 245-433-8
• MDL number: MFCD03990453
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24894920
• NACRES: NA.77

속성

• Product Name: Fumagillin from Aspergillus fumigatus, ≥90%, powder
• 생물학적 소스: Aspergillus sp. (Aspergillus fumigatus)
• Quality Level: 200
• 분석: ≥90%
• 양식: powder
• 색상: white
• mp: 197-198 °C
• solubility: ethanol: 1 mg/mL
• 항생제 활성 스펙트럼: fungi
• 동작 모드: DNA synthesis | interferes
• 저장 온도: −20°C
• SMILES string: COC1C(CCC2(CO2)C1C3(C)OC3C\C=C(\C)C)OC(=O)\C=C\C=C\C=C\C=C\C(O)=O
• InChI: 1S/C26H34O7/c1-18(2)13-14-20-25(3,33-20)24-23(30-4)19(15-16-26(24)17-31-26)32-22(29)12-10-8-6-5-7-9-11-21(27)28/h5-13,19-20,23-24H,14-17H2,1-4H3,(H,27,28)/b7-5+,8-6+,11-9+,12-10+
• InChI key: NGGMYCMLYOUNGM-HCNIIHBUSA-N

설명

일반 설명

Fumagillin is a metabolic product of fungi. It is originally isolated from Aspergillus fumigatus.

애플리케이션

Fumagillin from Aspergillus fumigatus has been used:

• in chick chorioallantoic membrane (CAM) assay to study the changes in protein expression in response to anti-angiogenic agent
• to study its effects on the mortality of caged Nosema ceranae-infected honey bees- write in this way
• as a positive control in in vitro and ex vivo studies

생화학적/생리학적 작용

Fumagillin is known to be effective against microsporidian fungal infections.

Methionine aminopeptidase-2 (MetAP-2) inhibitor; inhibits endothelial cell proliferation and angiogenesis.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302
• 예방조치 성명서: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves