F7807

Prostaglandin F Synthase human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

• 동의어(들): 17-beta-hydroxysteroid dehydrogenase type 5, AKR1C3, aldo-keto reductase family 1 member C3, indanol dehydrogenase
• CAS Number: 55976-95-9
• EC 번호: 1.1.1.188 (BRENDA, IUBMB)
• MDL number: MFCD00900598
• UNSPSC 코드: 12352204
• NACRES: NA.54

속성

• 재조합: expressed in E. coli
• Quality Level: 200
• 설명: contains a C-terminal hexahistidine tag
• 분석: ≥90% (SDS-PAGE)
• 양식: liquid
• 특이 활성도: ≥0.4 μmol/mg protein
• 분자량: ~37 kDa
• NCBI 수납 번호: NP_003730
• 배송 상태: dry ice
• 저장 온도: −70°C
• 유전자 정보: human ... AKR1C3(8644)

설명

애플리케이션

Prostaglandin F synthase (PGF synthase) is a member of the aldo-keto reductase superfamily of proteins which catalyze the conversion of aldehydes and ketones to thier corresponding alcohols. Prostaglandin F synthase is used in cancer research since it is upregulated in many cancers such as breast and prostate cancer. PGF synthase is also used to study kidney and renal cell carcinoma .

생화학적/생리학적 작용

PGF synthase catalyzes the conversions of 4-androstene-3,17-dione to testosterone, estrone to 17β-estradiol, prostaglandin H2 to PGF2α, and PGD2 to 9α,11β-PGF2. Prostaglandin (PG) F2 is synthesized via three pathways .

단위 정의

One unit is defined as the amount of enzyme required to produce 1 μmol of NADP per minute at 37°C in 50 mM KPO₄ pH 7.2 containing 250 μM NADPH and 25 μM 9,10-phenanthrenequinone

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable