F8648

Monoclonal Anti-Interferon-γ−Carboxyfluorescein antibody produced in mouse

clone 25723.11, purified immunoglobulin, buffered aqueous solution

• 동의어(들): Monoclonal Anti-Interferon-γ
• UNSPSC 코드: 51111800
• NACRES: NA.41

속성

• 생물학적 소스: mouse
• Quality Level: 200
• 결합: carboxyfluorescein conjugate
• 항체 형태: purified immunoglobulin
• 항체 생산 유형: primary antibodies
• 클론: 25723.11, monoclonal
• 양식: buffered aqueous solution
• 종 반응성: human
• 기술: flow cytometry: suitable
• 동형: IgG2b
• UniProt 수납 번호: P01579
• 배송 상태: wet ice
• 저장 온도: 2-8°C
• 유전자 정보: human ... IFNG(3458)

설명

일반 설명

Interferons (IFNs) are cytokines that are secreted in response to viral or bacterial infections and tumorigenesis. There are two types of IFNs, type I (IFN-α and IFN-β) and type II (IFN-γ). IFN-γ binds to specific receptor complex consisting of IFNγR1 and IFNγR2. There are many pathways that are mediated by IFN-γ binding such as JAK/STAT1, AP-1, NF-κB, STAT3 and STAT5. IFN-γ is pleotropic and performs various functions related to immune response, inflammation, differentiation and activation of T cells, cell cycle and apoptosis. The most studied function of IFN-γ is priming the antigen presenting cells by up regulating major histocompatibility (MHC) Class I molecules. IFN-γ has clinical applications in autoimmune diseases (rheumatoid arthritis), multiple sclerosis, cancer, HIV and fungal infections. Anti-Interferon-γ recognizes intracellular human IFN-γ. The product is prepared by conjugation of carboxyfluorescein to Protein G purified IFN-γ monoclonal antibody.

특이성

The conjugates will identify and quantitate cells containing intracellular forms of human IFN-γ by flow cytometry.

면역원

recombinant human IFN-γ

애플리케이션

Anti-interferon-γ antibody may be used for detection of intracellular IGN-γ in peripheral blood lymphocytes by adding 10 μL of the antibody to 1-5 X 10⁵ cells.

물리적 형태

Solution in phosphate buffered saline containing 0.1% sodium azide.

제조 메모

Purified antibody is conjugated to carboxyfluorescein.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)