F9765

Filipin complex

powder, ≥70% (UV)

• 동의어(들): Filimarisin
• CAS Number: 11078-21-0
• MDL number: MFCD00131073
• UNSPSC 코드: 12352202
• NACRES: NA.77

속성

• Product Name: Filipin complex from Streptomyces filipinensis, ≥70% (UV)
• 생물학적 소스: Streptomyces sp. (Streptomyces filipinensis)
• Quality Level: 200
• 분석: ≥70% (UV)
• 양식: powder
• solubility: methanol: 9.80-10.20 mg/mL, clear to hazy, yellow to very deep greenish-yellow
• 항생제 활성 스펙트럼: fungi
• 동작 모드: cell membrane | interferes
• 저장 온도: −20°C
• InChI: 1S/C35H58O11/c1-4-5-11-16-31(42)34-33(44)22-29(40)20-27(38)18-25(36)17-26(37)19-28(39)21-32(43)23(2)14-12-9-7-6-8-10-13-15-30(41)24(3)46-35(34)45/h6-10,12-15,24-34,36-44H,4-5,11,16-22H2,1-3H3/b7-6+,10-8+,12-9+,15-13+,23-14+/t24-,25+,26-,27+,28-,29+,30+,31-,32+,33+,34-/m1/s1
• InChI key: IMQSIXYSKPIGPD-YQRUMEKGSA-N

설명

일반 설명

Chemical structure: macrolide

애플리케이션

Filipin complex from Streptomyces filipinensis has been used as a profluorescence probe to detect the free cholesterol in cell.

생화학적/생리학적 작용

Filipin is a polyene macrolide antibiotic and antifungal. The antifungal mechanism of action is unclear but may be due to altering membrane permeability and associated functions via binding to membrane sterols. Filipin binds to membrane sterols such as cholesterol, and it both inhibits prion protein (PrP) endocytosis and causes the release of PrP from the plasma membrane.

Filipin is a polyene macrolide antibiotic and antifungal. The antifungal mechanism of action is unclear but may be due to altering membrane permeability. Filipin binds to model crystalline phase lipid bilayers containing cholesterol, and to liquid phase bilayers with or without cholesterol, in an orientation that forms membrane pores.It both inhibits prion protein (PrP) endocytosis and causes the release of PrP from the plasma membrane.

기타 정보

Filipin contains 8 isomeric components, with filipin III as the major component.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H315,H319,H335
• 예방조치 성명서: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable