G1044

Monoclonal Anti-Granzyme B antibody produced in mouse

clone GrB7, tissue culture supernatant

• 동의어(들): Anti-C11, Anti-CCPI, Anti-CGL-1, Anti-CGL1, Anti-CSP-B, Anti-CSPB, Anti-CTLA1, Anti-CTSGL1, Anti-HLP
• MDL number: MFCD01865484
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: mouse
• Quality Level: 200
• 결합: unconjugated
• 항체 형태: tissue culture supernatant
• 항체 생산 유형: primary antibodies
• 클론: GrB7, monoclonal
• 설명: not suitable for immunocytochemistry (frozen sections)
• 분자량: antigen 33 kDa
• 종 반응성: human
• 기술: immunocytochemistry: 1:20 using pretreated tissues; western blot: suitable
• UniProt 수납 번호: P10144
• 배송 상태: dry ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... GZMB(3002)

설명

특이성

Does not cross-react with granzyme A.

면역원

recombinant human granzyme B.

애플리케이션

Monoclonal Anti-Granzyme B antibody is suitable for western blot and immunocytochemistry at a dilution of 1:20 using pretreated tissues.

생화학적/생리학적 작용

Granzyme B, neutral serine protease, is expressed in cytoplasmic granules of activated cytotoxic T lymphocytes and natural killer cells. It contains a leader sequence (cleaved by a signal peptidase) and two amino acid prodomains (cleaved by the lysosomal cysteine protease DPPI). It plays a major role in the caspase dependent apoptotic pathway by activating most of the caspases in vitro and in vivo. It cleaves the aspartic acid residues, to facilitate cell death by various pathways. It has been shown that granzyme B has capacity to facilitate cytochrome C release from the mitochondria in a caspase independent way.

물리적 형태

Supplied in serum-free culture medium containing 1% bovine serum albumin and 0.1% sodium azide.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable