G117

Glipizide

solid

• 동의어(들): 1-Cyclohexyl-3-{4-[2-(5-methylpyrazine-2-carboxamido)ethyl]phenylsulfonyl}urea
• 실험식(Hill 표기법): C₂₁H₂₇N₅O₄S
• CAS Number: 29094-61-9
• Molecular Weight: 445.54
• EC Number: 249-427-6
• MDL number: MFCD00072159
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24277839
• NACRES: NA.77

속성

• 양식: solid
• Quality Level: 100
• 색상: white
• solubility: methanol: 1.9 mg/mL; DMSO: 48 mg/mL
• SMILES string: Cc1cnc(cn1)C(=O)NCCc2ccc(cc2)S(=O)(=O)NC(=O)NC3CCCCC3
• InChI: 1S/C21H27N5O4S/c1-15-13-24-19(14-23-15)20(27)22-12-11-16-7-9-18(10-8-16)31(29,30)26-21(28)25-17-5-3-2-4-6-17/h7-10,13-14,17H,2-6,11-12H2,1H3,(H,22,27)(H2,25,26,28)
• InChI key: ZJJXGWJIGJFDTL-UHFFFAOYSA-N
• 유전자 정보: human ... ABCC8(6833), KCNJ1(3758), KCNJ11(3767)

설명

일반 설명

Potassium inwardly-rectifying channel, subfamily J, member 1 (KCNJ1) codes for a renal outer medullary potassium channel (ROMK1, Kir1.1). Glipizide is an antidiabetic drug, that is used to treat type II diabetes.(5)

애플리케이션

Glipizide has been used in:

• chick embryo yolk sac membrane (YSM) and chorioallantoic membrane (CAM) assay
• MCF-7 breast cancer assay on chorioallantoic membrane (CAM)
• metastasis assays
• rat aortic ring assay
• in vivo matrigel plug assay
• 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay
• flow cytometry
• western blotting

생화학적/생리학적 작용

Potassium inwardly-rectifying channel, subfamily J, member 1 (KCNJ1) plays a vital role in potassium balance. It is an ATP-dependent K⁺ channel blocker. The encoded protein is liable for the elimination of potassium in exchange for the absorption of sodium by the epithelial sodium channel (ENaC). Mutation in KCNJ1 is linked with several diseases, such as, antenatal Bartter syndrome and diabetes. Glipizide helps to repress the development of tumors and metastasis by preventing angiogenesis.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)