G3046

GDF-15 human

• 동의어(들): Growth differentiation factor 15, MIC-1, Macrophage inhibitory cyotkine-1
• CAS Number: 1821355-80-9
• UNSPSC 코드: 12352202
• NACRES: NA.26

속성

• 생물학적 소스: human
• Quality Level: 100
• 재조합: expressed in CHO cells
• 분석: >97% (visualized with silver stain, SDS-PAGE)
• 양식: lyophilized powder
• 분자량: dimer 13 kDa (based on N-terminal sequencing, starting at the first histidine of the 6X histidine tag)
• 기술: cell culture | mammalian: suitable
• 불순물: endotoxin, tested
• UniProt 수납 번호: Q99988
• 저장 온도: −20°C
• 유전자 정보: human ... GDF15(9518)

설명

일반 설명

Growth-differentiation factor-15 (GDF-15) is a stress-responsive member of the transforming growth factor-β cytokine superfamily. It is also known as PTGF-Growth-differentiation factor-15 (GDF-15) and is a stress-responsive member of the transforming growth factor-β cytokine superfamily.² It is also known as PTGF-β, TGF-PL or MIC-1β, TGF-PL or MIC-1.

애플리케이션

Growth-differentiation factor-15 (GDF-15) has been associated in the regulation of cell survival, proliferation, and differentiation and also in the protection from ischemia/reperfusion injury. Inflammatory and apoptotic pathways are regulated in injured tissues by GDFs during disease processes.

생화학적/생리학적 작용

Although it has been classified as a divergent member of the transforming growth factor-β superfamily, GDF-15 shares structural characteristics with this superfamily. It has been identified as a biomarker for human prostate cancer. Additionally, increased GDF-15 expression has been observed in breast, pancreas and colorectal cancers. Functions of this cytokine include inhibition of TNF-α production, initiation of cartilage formation, and promotion of neuronal survival.
It has been discussed to serve as a secreted biomarker for activation of the p53 pathway in human cancer.

물리적 형태

Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile, 0.1% trifluoroacetic acid containing 50 μg of bovine serum albumin per 1 μg of GDF-15.

분석 메모

Under reducing conditions in SDS-PAGE, each recombinant GDF-15 monomer migrates as an ~14 kDa protein.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable