추천 제품
생물학적 소스
bovine plasma
Quality Level
분석
≥99%
양식
powder
기술
electrophoresis: suitable
mass spectrometry (MS): suitable
UniProt 수납 번호
저장 온도
2-8°C
유전자 정보
bovine ... ORM1(497200)
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일반 설명
α1-Acid Glycoprotein (AGP, orosomucoid) from bovine plasma belongs to ‘lipocalins′ family which binds and transports small hydrophobic molecules. AGP is further classified into the subfamily ‘immunocalins′ which immunomodulates the inflammatory reactions. AGP is primarily produced in the liver, in few extra hepatic tissues and is present in neutrophil granules. Healthy cattle possesses 0.3 mg of AGP/ ml of concentrated serum.
α1-Acid glycoprotein (AGP, orosomucoid) is the major plasma glycoprotein with a molecular weight of 41-43 kDa. It is responsible for possessing the complex type of glycans.
애플리케이션
α1-Acid Glycoprotein (AGP) from bovine plasma has been used:
- in mass spectrometry analysis to confirm the presence of Neu5Ac and Neu5Gc distribution in human and bovine AGP respectively
- for pretreating the microvessel before perfusing the MDA-MB-231 cells for tumor adhesion studies
- in the composition of tear model
- as a reference in sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE)
α1-Acid glycoprotein was used to study nonviral gene delivery to the lung with copolymer-protected and transferrin-modified polyethylenimine
생화학적/생리학적 작용
α1-Acid Glycoprotein from bovine plasma is an acute phase protein. It has anti-inflammatory potential and its concentration increases several folds during injury. AGP increases the chemotactic activity and life span of monocytes and inhibits neutrophil degranulation. Serum AGP levels differentiates sepsis from systemic inflammatory response syndrome (SIRS).
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
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