G5779

Gly-Pro-Arg-Pro amide

≥97% (HPLC)

• 동의어(들): GPRP amide, Glycine-Proline-Arginine-Proline amide, Glycyl-L-prolyl-L-arginyl-L-prolinamide
• 실험식(Hill 표기법): C₁₈H₃₂N₈O₄
• CAS Number: 126047-75-4
• Molecular Weight: 424.50
• MDL number: MFCD00237962
• UNSPSC 코드: 12352209
• PubChem Substance ID: 24895231
• NACRES: NA.32

속성

• Quality Level: 200
• 분석: ≥97% (HPLC)
• UniProt 수납 번호: P02751; P04937; P11276
• 저장 온도: −20°C
• SMILES string: NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N2CCC[C@H]2C(N)=O
• InChI: 1S/C18H32N8O4/c19-10-14(27)25-8-3-6-13(25)16(29)24-11(4-1-7-23-18(21)22)17(30)26-9-2-5-12(26)15(20)28/h11-13H,1-10,19H2,(H2,20,28)(H,24,29)(H4,21,22,23)/t11-,12-,13-/m0/s1
• InChI key: SCCTZYGEMPQRCV-AVGNSLFASA-N
• 유전자 정보: human ... FN1(2335) ; mouse ... FN1(14268) ; rat ... FN1(25661)

설명

Amino Acid Sequence

Gly-Pro-Arg-Pro-NH2

일반 설명

Gly-Pro-Arg-Pro is a peptide that mimics the N-terminal Gly-Pro-Arg region in the a chain of fibrin protein.

애플리케이션

Gly-Pro-Arg-Pro amide has been used-

• as a constituent of buffer during fluid-phase and bound thrombin inhibition assays, to determine the activity of thrombin
• for blocking fibrin polymerization and preventing fibrin clot formation in presence of α-thrombin, in blood obtained from mice
• during preparation of human soluble fibrin, to block the polymerization of soluble fibrin

생화학적/생리학적 작용

Gly-Pro-Arg-Pro peptide suppresses the early steps of fibrin polymerization. The amide derivative of this peptide prevents the degradation of fibrinogen and fragment D by plasmin, even in the presence of EGTA (ethylene glycol-bis(β-aminoethyl ether)-N,N,N′,N′-tetraacetic acid).

포장

Bottomless glass bottle. Contents are inside inserted fused cone.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)