Name: Gemcitabine hydrochloride
Brand: SIGMA

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About This Item

실험식(Hill 표기법):

C₉H₁₁F₂N₃O₄ · HCl

CAS Number:

122111-03-9

Molecular Weight:

299.66

MDL number:

MFCD01735988

UNSPSC 코드:

12352200

PubChem Substance ID:

329799951

NACRES:

NA.77

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도움 문의

Product Name

Gemcitabine hydrochloride, ≥98% (HPLC)

Quality Level

100

분석

≥98% (HPLC)

양식

powder

저장 조건

desiccated
protect from light

solubility

H₂O: ≥10 mg/mL

주관자

Eli Lilly

저장 온도

room temp

SMILES string

Cl.NC1=NC(=O)N(C=C1)[C@@H]2O[C@H](CO)[C@@H](O)C2(F)F

InChI

1S/C9H11F2N3O4.ClH/c10-9(11)6(16)4(3-15)18-7(9)14-2-1-5(12)13-8(14)17;/h1-2,4,6-7,15-16H,3H2,(H2,12,13,17);1H/t4-,6-,7-;/m1./s1

InChI key

OKKDEIYWILRZIA-OSZBKLCCSA-N

유전자 정보

human ... POLA1(5422), POLA2(23649), POLD1(5424), POLD2(5425), POLD3(10714), POLD4(57804), POLE(5426), POLE2(5427), POLE3(54107), PRIM1(5557), PRIM2(5558), RRM1(6240), RRM2(6241), RRM2B(50484)

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일반 설명

Gemcitabineis a pyrimidine nucleoside analog of deoxycytidine. It exhibits anticancereffects against various cancers.

애플리케이션

Gemcitabinehydrochloride has been used as a chemotherapeutic agent to study its effects onthe human pancreatic adenocarcinoma cell lineIt has been used as a chemotherapeutic to study its resistance inpancreatic stellate cells (PSCs)It has also been used to study its effects on patient-derivedxenograft (PDX) organoids.

생화학적/생리학적 작용

Gemcitabine is a widely used antitumor agents in both clinics and research labs. It is an antineoplastic agent and antimetabolite.

특징 및 장점

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.