G6776

Genistein

from Glycine max (soybean), ~98% (HPLC)

• 동의어(들): 4′,5,7-Trihydroxyisoflavone, 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
• 실험식(Hill 표기법): C₁₅H₁₀O₅
• CAS Number: 446-72-0
• Molecular Weight: 270.24
• Beilstein: 263823
• EC Number: 207-174-9
• MDL number: MFCD00016952
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24895273
• NACRES: NA.77

속성

• 생물학적 소스: Glycine max (soybean)
• Quality Level: 200
• 분석: ~98% (HPLC)
• 양식: powder
• mp: >280 °C
• solubility: DMSO: soluble; ethanol: soluble
• 저장 온도: −20°C
• SMILES string: Oc1ccc(cc1)C2=COc3cc(O)cc(O)c3C2=O
• InChI: 1S/C15H10O5/c16-9-3-1-8(2-4-9)11-7-20-13-6-10(17)5-12(18)14(13)15(11)19/h1-7,16-18H
• InChI key: TZBJGXHYKVUXJN-UHFFFAOYSA-N
• 유전자 정보: human ... AKT1(207), CYP19A1(1588), EGFR(1956), ESR1(2099), ESR2(2100) ; mouse ... Esr1(13982), Hexa(15211) ; rat ... Adora1(29290), Adora2a(25369), Ar(24208)

설명

일반 설명

Genistein is a nutraceutical isoflavnoid from soybean and is a phytoestrogen. It is derived from genistin.

애플리케이션

Genistein has been used:

• as an anticancer agent to test its cytotoxicity in cervix adenocarcinoma cells
• as a polyphenol to test its effect on reactive oxygen species in mitochondria from sperm
• to test its radical scavenging effect on the UV irradiated in dermal and keloid fibroblasts

생화학적/생리학적 작용

Genistein has antioxidant functionality and is effective in quenching reactive oxygen species. It is beneficial to human health.

Inhibitor of tyrosine protein kinase; competitive inhibitor of ATP in other protein kinase reactions. Antiangiogenic agent, down-regulates the transcription of genes involved in controlling angiogenesis.

특징 및 장점

This compound is featured on the Met page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302
• 예방조치 성명서: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type N95 (US)