G9665

Anti-Glutamate Receptor 1A, Metabotropic (mGluR1A) antibody produced in rabbit

affinity isolated antibody, buffered aqueous glycerol solution

• MDL number: MFCD01633637
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 200
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 양식: buffered aqueous glycerol solution
• 종 반응성: mouse, feline, rat
• 기술: immunohistochemistry (frozen sections): 1:500; western blot: 1:1,000
• UniProt 수납 번호: P23385
• 배송 상태: dry ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: mouse ... Grm1(14816) ; rat ... Grm1(24414)

설명

일반 설명

The metabotropic glutamate receptors consist of eight subtypes (mGluR1-8) divided into three groups (I-III). Glutamate is the main excitatory neurotransmitter in the brain. It acts on ligand-gated receptor channels, termed NMDA, AMPA and kainate receptors, involved in the fast excitatory synaptic transmission. Glutamate also regulates ion channels and enzymes producing second messengers via specific receptors coupled to G-proteins, called metabotropic glutamate receptors.

특이성

This antibody does not react with other splice variants or mGluR5.

면역원

synthetic peptide corresponding to the sequence of amino acids 1116-1130 of rat metabotropic glutamate receptor 1A (mGluR1a).

애플리케이션

Anti-Glutamate Receptor 1A, Metabotropic (mGluR1A) antibody produced in rabbit is suitable for use as a primary antibody at a working dilution of 1:1500 using extracts from mouse brain It is suitable for immunohistochemistry at a working dilution of 1:500 and for immunoblotting at a working dilution of 1:1000.

생화학적/생리학적 작용

Glutamate Receptor 1 is a G-protein coupled receptor for glutamate. The role of the metabotropic receptors in pain and pathology is being studied for therapeutic potential. Glutamate receptors are important mediators of excitatory amino acid neurotransmission. The α isomer of this receptor is a disulfide-linked homodimer and its activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. Mutations in this gene causes autosomal-recessive congenital cerebellar ataxia.

물리적 형태

10 mM HEPES (pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50% glycerol

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable