H4381

6-Hydroxydopamine hydrochloride

≥97% (titration), powder, neurotoxin

• 동의어(들): 2,4,5-Trihydroxyphenethylamine hydrochloride, 2,5-Dihydroxytyramine hydrochloride, 2-(2,4,5-Trihydroxyphenyl)ethylamine hydrochloride, 6-OHDA
• Linear Formula: (HO)₃C₆H₂CH₂CH₂NH₂ · HCl
• CAS Number: 28094-15-7
• Molecular Weight: 205.64
• Beilstein: 4274007
• EC Number: 248-837-2
• MDL number: MFCD00012895
• UNSPSC 코드: 12352116
• PubChem Substance ID: 24895641
• NACRES: NA.77

속성

• Product Name: 6-Hydroxydopamine hydrochloride, ≥97% (titration), powder
• Quality Level: 100
• 분석: ≥97% (titration)
• 양식: powder
• 색상: off-white to brown
• mp: 232-233 °C (dec.) (lit.)
• solubility: H₂O: >50 mg/mL, clear, yellow to brown
• 저장 온도: room temp
• SMILES string: Cl.NCCc1cc(O)c(O)cc1O
• InChI: 1S/C8H11NO3.ClH/c9-2-1-5-3-7(11)8(12)4-6(5)10;/h3-4,10-12H,1-2,9H2;1H
• InChI key: QLMRJHFAGVFUAC-UHFFFAOYSA-N

설명

일반 설명

6-Hydroxydopamine hydrochloride (6-OHDA) is a neurotoxin, commonly used to induce Parkinson′s disease (PD). 6-OHDA causes death of dopaminergic neurons in substantia nigra pars compacta progressively mimicking PD. 6-OHDA is highly oxidizable and cannot cross blood brain barrier. 6-OHDA exerts cytotoxicity by generating reactive oxygen species, initiating cellular stress and cell death. 6-OHDA leads to neuronal cell death in many in vitro models like primary neuronal culture, human neuroblastoma cell line and rat adrenal pheochromocytoma cell line, PC12.

애플리케이션

6-hydroxydopamine hydrochloride has been used:

• to induce Parkinson′s disease (PD) in rats
• to analyse cytotoxic effect of 6-OHDA on PC12 cell line
• to induce noradrenergic (NA) neuron deletion from the locus-coeruleus

생화학적/생리학적 작용

Neurotoxin that destroys catecholaminergic terminals.

주의사항

Hygroscopic

재구성

Dissolve in oxygen-free water containing 0.1% sodium metabisulfite or other antioxidants.

Solutions should be freshly prepared and protected from exposure to light. Solutions turn red as it oxidizes.

기타 정보

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H315,H319,H335
• 예방조치 성명서: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves