H5160

Hyperforin

≥85% (HPLC)

• 실험식(Hill 표기법): C₃₅H₅₂O₄
• CAS Number: 11079-53-1
• Molecular Weight: 536.78
• EC Number: 200-659-6
• MDL number: MFCD01861497
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329815216
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥85% (HPLC)
• 양식: solution
• 저장 온도: −20°C
• SMILES string: CC(C)C(=O)[C@@]12C(O)=C(C\C=C(\C)C)C(=O)[C@@](C\C=C(/C)C)(C[C@H](C\C=C(\C)C)[C@@]1(C)CC\C=C(\C)C)C2=O
• InChI: 1S/C35H52O4/c1-22(2)13-12-19-33(11)27(16-14-23(3)4)21-34(20-18-25(7)8)30(37)28(17-15-24(5)6)31(38)35(33,32(34)39)29(36)26(9)10/h13-15,18,26-27,38H,12,16-17,19-21H2,1-11H3/t27-,33+,34+,35-/m0/s1
• InChI key: IWBJJCOKGLUQIZ-HQKKAZOISA-N

설명

일반 설명

Hyperforin is a phloroglucinol component of St. John′s wort and a pregnane X receptor ligand.

애플리케이션

Hyperforin may be used:

• as a reference standard for calibration curve generation in high-perfornamce liquid chromatography (HPLC) analysis
• to test its cytotoxic effect and apoptosis induction in mouse embryonic cells
• as a pregnane X receptor (PXR) in porcine brain capillary endothelial cells for transport assay

생화학적/생리학적 작용

Hyperforin is an active antidepressant and an inhibitor of cytochrome P450 3A4 (CYP3A). It elicits antioxidant and antibacterial activity. Hyperforin is also embryotoxic and inhibits tumor proliferation. It effectively inhibits dopamine, serotonin and norepinephrine.

안전성 정보

• 픽토그램: GHS02,GHS06,GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H225,H301 + H311 + H331,H370
• 예방조치 성명서: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• 표적 기관: Eyes
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 2
• Flash Point (°F): 49.5 °F - closed cup
• Flash Point (°C): 9.7 °C - closed cup
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)