H6161

[Gly¹⁴]-Humanin G human

≥95% (HPLC), powder

• 동의어(들): S14G-humanin, HNG
• MDL number: MFCD03787971
• UNSPSC 코드: 12352209
• NACRES: NA.32

속성

• 생물학적 소스: human
• Quality Level: 200
• 분석: ≥95% (HPLC)
• 양식: powder
• 분자량: 2654.2-2660.2 Da
• 저장 조건: (Keep container tightly closed in a dry and well-ventilated place)
• 기술: activity assay: suitable
• solubility: water: 1.00-1.04 mg/mL, clear, colorless
• 배송 상태: dry ice
• 저장 온도: −20°C
• SMILES string: S(CC[C@H](N)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](CO)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCC(=O)N[C@@H](
• InChI: 1S/C118H202N34O31S2/c1-19-65(14)92(112(179)144-81(54-90(159)160)104(171)145-82(52-63(10)11)114(181)152-46-29-37-86(152)109(176)148-91(64(12)13)111(178)139-72(32-23-24-41-119)97(164)137-74(35-27-44-129-118(125)126)98(165)136-73(34-26-43-128-117(123)124)96(
• InChI key: WUYRHUFIUFJVQU-XJUNAYMOSA-N

설명

Amino Acid Sequence

Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Gly-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala

일반 설명

Research area: Neuroscience

[Gly14]-humanin (HNG) belongs to the family of mitochondrial-derived peptides. HNG (humanin-G) is an analog of humanin, generated by S14G (serine-14-glycine) mutation. HNG shows a 1000 times stronger activity.

애플리케이션

[Gly14]-Humanin G human has been used:

• along with bortezomib in pharmacological inhibition studies to treat mice to limit the toxic effects of bortezomib
• to study its effect on high glucose (HG)-induced apoptosis of endothelial cells (ECs)
• to study its neuroprotective effects in an in vitro oxygen-glucose deprivation/reoxygenation (OGD/R) model using SH-SY5Y neuroblastoma cells

[Gly¹⁴]-Humanin G human has been used to limit the toxicity during the bortezomib treatment in neonatal brachial plexus injury (NBPI) mice model. It has also been used in the cell culture of the human-derived neuroblastoma cell line.

생화학적/생리학적 작용

Endogenous rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer′s disease genes and Aβ

Endogenous rescue factor abolishing neuronal cell death by many familial Alzheimer′s disease genes.

[Gly14]-humanin (HNG) stimulates cell growth, proliferation, and cell cycle progression. It enhances proteins such as kinases, transporters, transmembrane receptors, and transcription and translational regulators. HNG exhibits intense in vitro neuroprotective effects compared to natural HN. Studies show that it is an effective cytoprotectant both in vitro and in vivo. HNG is found to prevent high glucose (HG)-induced apoptosis of endothelial cells (ECs). It is proven to inhibit AngII-induced phenotypic switch in vascular smooth muscle cells (VSMCs).

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)