I2658

Anti-phospho-Insulin Receptor Substrate-1 (pTyr⁶¹²) antibody produced in rabbit

affinity isolated antibody, buffered aqueous glycerol solution

• 동의어(들): Anti-phospho-IRS-1 (pTyr⁶¹²)
• MDL number: MFCD05865378
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 200
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 양식: buffered aqueous glycerol solution
• 종 반응성: human
• 포장: vial of 100 μL
• 기술: western blot: suitable
• UniProt 수납 번호: P35568
• 배송 상태: wet ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: phosphorylation (pTyr612)
• 유전자 정보: human ... IRS1(3667)

설명

일반 설명

Assay Dependent. It is recommended that the user determine the appropriate working dilution for their process.

Insulin receptor substrate-1 (IRS-1) is among the four IRS proteins (IRS-1-IRS-4) that mediate signalling by insulin receptor (IR) and insulin-like growth factor (IGF) receptor. IRS-1 has a pleckstrin homology domain and a phosphotyrosine-binding domain. . Phosphorylation of Tyr⁶¹² and Tyr⁶³² fully activate the PI3K signalling pathway in response to insulin and induce translocation of GLUT4. Thus IRS-1 protein plays a vital role in mediating the metabolic actions of insulin via the PI3K pathway. Additionally, IRS-1 has the abililty to translocate to the nucleus, the mechanism of which is not very clear. The transcriptional activity of IRS-1 is involved in the development of breast and prostate cancers
The antibody recognizes human IRS-1 (pTyr⁶¹²). It may cross react with in mouse, rat and chicken (100% homologous) IRS-1 (pTyr⁶¹²).

면역원

synthetic phosphopeptide derived from the region of insulin receptor substrate-1 (IRS-1) phosphorylated at tyrosine 612.

애플리케이션

Anti-phospho-IRS-1 (pTyr⁶¹²) antibody may be used for detection by immunoblotting.

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

물리적 형태

Solution in Dulbecco′s PBS, pH 7.3, 50% glycerol containing 1 mg/ml BSA and ≤ 0.1% sodium azide.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)