I2778

IL-1α human

≥98% (SDS-PAGE and HPLC), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

• 동의어(들): IL-1α, hIL-1α., Interleukin-1α human, Lymphocyte activating factor
• MDL number: MFCD00164814
• UNSPSC 코드: 12352202
• NACRES: NA.77

속성

• Product Name: Interleukin-1α human, IL-1α, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
• 생물학적 소스: human
• Quality Level: 100
• 재조합: expressed in E. coli
• 분석: ≥98% (SDS-PAGE and HPLC)
• 양식: lyophilized powder
• 품질: endotoxin tested
• 분자량: ~17 kDa
• 포장: pkg of 2 and 10 μg
• 기술: cell culture | mammalian: suitable
• UniProt 수납 번호: P01583
• 저장 온도: −20°C
• 유전자 정보: human ... IL1A(3552)

설명

일반 설명

Interleukin-1α (IL-1α) is a cytokine that belongs to the interleukin-1 (IL-1) family. It is located intracellularly in hematopoietic and non-hematopoietic cells. IL-1α gene is located on the human chromosome at 2q14.1.

애플리케이션

Interleukin-1α (IL-1α) has been used:

• to study its effects on human colorectal adenocarcinoma cells
• to stimulate primary human fetal retinal pigment epithelium (hfRPE) cells
• to pre-stimulate human THP-1 monocytes

생화학적/생리학적 작용

Interleukin-1α (IL-1α) plays a crucial role in inflammation during cell necrosis. It also regulates the recruitment of interleukin-1β (IL-1β), neutrophils, chemokines, and other cytokines at the site of injury. IL-1α exhibits a dual function of binding to its cell surface receptor as well as chromatin.

물리적 형태

Lyophilized from 0.2 μm filtered 10 mM sodium phosphate , pH 8.0, plus 50 mm NaCl and 50 μg bovine serum albumin (BSA) per μg cytokine.

분석 메모

The proliferative activity of human IL-1α is tested in culture using the murine cell line D10S.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H315,H319,H335
• 예방조치 성명서: P261 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves