I4276

Interferon-αA human

≥95%, suitable for cell culture, buffered aqueous solution, recombinant, expressed in E. coli

• 동의어(들): IFN-αA, Interferon-α2A
• CAS Number: 105388-21-4
• MDL number: MFCD01635115
• UNSPSC 코드: 12352202
• NACRES: NA.32

속성

• 생물학적 소스: human
• Quality Level: 200
• 재조합: expressed in E. coli
• 분석: ≥95%
• 양식: buffered aqueous solution
• 분자량: 19 kDa
• 포장: pkg of 20 μg
• 농도: ≥0.2 mg/mL
• 기술: cell culture | mammalian: suitable
• 불순물: endotoxin, tested
• 색상: colorless
• UniProt 수납 번호: P01563
• 배송 상태: wet ice
• 저장 온도: −20°C
• 유전자 정보: human ... IFNA2(3440)

설명

애플리케이션

Interferon-αA human has been used to:

• study the effect of Chikungunya virus on interferon-mediated JAK (Janus kinase)-STAT (signal transducers and activators of transcription) signaling
• study the effect of interferon-α and PRK2 (protein kinase C-related kinase 2) inhibitors on hepatitis C virus replication
• compare the effect of Monascus pigment derivatives on hepatitis C virus replication

생화학적/생리학적 작용

Cytokine with anti-viral, anti-proliferative, immunoregulatory, and proinflammatory activities.

Cytokine with anti-viral, anti-proliferative, immunoregulatory, and proinflammatory activities. Type I Interferons are a closely related family of 165-172 amino acid proteins that are produced by leukocytes (α subtypes), fibroblasts (β subtypes), lymphocytes (ω subtypes) and ruminant embryos (τ subtypes). Interferon induces a variety of effects on target cells including antiviral, antiproliferative and immunomodulatory activities.

물리적 형태

Supplied as a solution in 5 mM sodium acetate, pH 4.0.

분석 메모

The biological activity is determined in the cytopathic effect inhibition assay using MDBK cells with vesicular stomatitis virus (VSV). A cytopathic effect of 50% is produced with 1 unit/ml interferon. The units are determined with respect to WHO International standard reference for human interferonαA.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves