I6256

2-Iminothiolane hydrochloride

≥98% (TLC), powder

• 동의어(들): 2-Thiolanimine hydrochloride, 2IT, Dihydro-2(3H)-thiophenimine hydrochloride, Traut’s reagent
• 실험식(Hill 표기법): C₄H₇NS · HCl
• CAS Number: 4781-83-3
• Molecular Weight: 137.63
• Beilstein: 3620079
• MDL number: MFCD00039013
• UNSPSC 코드: 12352100
• PubChem Substance ID: 24896086
• NACRES: NA.21
• solubility: H₂O: 100 mg/mL

속성

• Quality Level: 200
• 분석: ≥98% (TLC)
• 양식: powder
• 불순물: ≤5% Free sulfhydryl groups
• mp: 198-201 °C (lit.)
• solubility: H₂O: 100 mg/mL
• 작용기: thioether
• 저장 온도: 2-8°C
• SMILES string: N=C1SCCC1.Cl
• InChI: 1S/C4H7NS.ClH/c5-4-2-1-3-6-4;/h5H,1-3H2;1H
• InChI key: ATGUDZODTABURZ-UHFFFAOYSA-N

설명

일반 설명

2-Iminothiolane hydrochloride (2-IT.HCl), a protein modification reagent, is commonly employed to attach thiol groups to proteins and peptides. Raman spectroscopic analysis of hair keratin fibers modified with 2-IT.HCl showed the formation of new disulfide groups.

애플리케이션

2-Iminothiolane hydrochloride has been used in the synthesis of thiolated PEG (poly(ethylene glycol). It may be used to synthesize PLA-SH (polyethylene glycol-thiol) and PLA-PEG-SH (polyethylene glycol–polylactic acid-thiol).

Thiolating reagent for primary amines. Reacts at pH 7-10 by amidine bond to present free sulfhydryl. Useful in preparation of disulfide and/or thioether linked conjugates.

기타 정보

Note that the amidine linkage preserves original primary amine positive charge. Incorporates a five atom linker.

안전성 정보

• 픽토그램: GHS06
• 신호어: Danger
• 유해 및 위험 성명서: H301
• 예방조치 성명서: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)