J4455

JSH-23

≥98% (HPLC), solid

• 동의어(들): 4-methyl-N1-(3-phenylpropyl)-1,2-benzenediamine
• 실험식(Hill 표기법): C₁₆H₂₀N₂
• CAS Number: 749886-87-1
• Molecular Weight: 240.34
• UNSPSC 코드: 51111800
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: solid
• 저장 조건: protect from light
• 색상: off-white to gray-pink
• solubility: DMSO: >10 mg/mL
• 배송 상태: wet ice
• 저장 온도: −20°C
• SMILES string: N(CCCc2ccccc2)c1c(cc(cc1)C)N
• InChI: 1S/C16H20N2/c1-13-9-10-16(15(17)12-13)18-11-5-8-14-6-3-2-4-7-14/h2-4,6-7,9-10,12,18H,5,8,11,17H2,1H3
• InChI key: YMFNPBSZFWXMAD-UHFFFAOYSA-N

설명

애플리케이션

JSH-23 has been used as a nuclear factor κB (NF-κB) p65 inhibitor.

생화학적/생리학적 작용

JSH-23 is an inhibitor of NF-kB nuclear translocation.

JSH-23 is an inhibitor of NF-kB nuclear translocation. It inhibits LPS and cytokine-induced nuclear translocation of the p65 subunit of NF-kB as analyzed by EMSA and western blot. The compound displays modest potency (IC50 7.1 uM in RAW 264.7), but has the unique property that it does not affect IkB degradation or recovery. The compound dose dependently inhibits LPS induced expression of cytokines, COX2 and iNOS, and presumably binds to, or interferes with the NLS of p65.

기타 정보

Light and air sensitive.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3