추천 제품
Quality Level
분석
≥98% (HPLC)
양식
solid
저장 조건
protect from light
색상
off-white to gray-pink
solubility
DMSO: >10 mg/mL
배송 상태
wet ice
저장 온도
−20°C
SMILES string
N(CCCc2ccccc2)c1c(cc(cc1)C)N
InChI
1S/C16H20N2/c1-13-9-10-16(15(17)12-13)18-11-5-8-14-6-3-2-4-7-14/h2-4,6-7,9-10,12,18H,5,8,11,17H2,1H3
InChI key
YMFNPBSZFWXMAD-UHFFFAOYSA-N
관련 카테고리
애플리케이션
JSH-23 has been used as a nuclear factor κB (NF-κB) p65 inhibitor.
생화학적/생리학적 작용
JSH-23 is an inhibitor of NF-kB nuclear translocation.
JSH-23 is an inhibitor of NF-kB nuclear translocation. It inhibits LPS and cytokine-induced nuclear translocation of the p65 subunit of NF-kB as analyzed by EMSA and western blot. The compound displays modest potency (IC50 7.1 uM in RAW 264.7), but has the unique property that it does not affect IkB degradation or recovery. The compound dose dependently inhibits LPS induced expression of cytokines, COX2 and iNOS, and presumably binds to, or interferes with the NLS of p65.
기타 정보
Light and air sensitive.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
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