K0133

Kaempferol

≥90% (HPLC), powder

• 동의어(들): 3,4′,5,7-Tetrahydroxyflavone, 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one, Robigenin
• 실험식(Hill 표기법): C₁₅H₁₀O₆
• CAS Number: 520-18-3
• Molecular Weight: 286.24
• Beilstein: 304401
• MDL number: MFCD00016938
• UNSPSC 코드: 12191503
• PubChem Substance ID: 24896195
• NACRES: NA.25

속성

• 생물학적 소스: synthetic
• Quality Level: 100
• 분석: ≥90% (HPLC)
• 양식: powder
• 저장 조건: protect from light
• 색상: yellow
• mp: 277 °C
• solubility: ethanol: 20 mg/mL; DMSO: 50 mg/mL
• 저장 온도: room temp
• SMILES string: Oc1ccc(cc1)C2=C(O)C(=O)c3c(O)cc(O)cc3O2
• InChI: 1S/C15H10O6/c16-8-3-1-7(2-4-8)15-14(20)13(19)12-10(18)5-9(17)6-11(12)21-15/h1-6,16-18,20H
• InChI key: IYRMWMYZSQPJKC-UHFFFAOYSA-N
• 유전자 정보: human ... CDC2(983), CDK5(1020), CDK6(1021), CYP1A2(1544), CYP2C9(1559), GSK3A(2931) ; mouse ... Hexa(15211)

설명

일반 설명

Kaempferol is a natural dietary flavonoid and a polyphenol antioxidant found in various fruits and vegetables. Kaempferol is present in plants in a different glycosidic form such as astragalin by binding with different sugars.

애플리케이션

Chromogenic reagent for antimony in the low ppm range and for gallium and indium in the sub-ppm range.

Kaempferol (KAE) has been used:

• to check its potential effect as an antioxidant and neuroprotective agent against rotenone-induced Parkinson′s disease (PD) model in SH-S5Y5 cells
• to test its anti-inflammatory effect on lipopolysaccharide (LPS)-induced inflammatory injury in human aortic endothelial cells (HAECs)
• to study its apoptosis sensitizing effect on non-small cell lung cancer (NSCLC) cells by inhibiting nuclear factor erythroid 2-related factor 2 (Nrf2)

생화학적/생리학적 작용

Potent inhibitor of osteoclastic bone resorption. The effect is believed to be attributable to both the antioxidant and estrogenic activities of kaempferol.

The diphenylpropane component of Kaempferol contributes to its hydrophobic properties. It has shown to revert the transformed phenotype of phorbol ester-treated mouse fibroblasts or v-H-ras-transformed NIH 3T3 cells. Kaempferol induces significant nuclear DNA degradation concurrent with lipid peroxidation. It also inhibits topoisomerase I catalyzed DNA religation. Kaempferol may also inhibit the activity of fatty acid synthase.

포장

Bottomless glass bottle. Contents are inside inserted fused cone.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302
• 예방조치 성명서: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges