K1514

Kurtoxin

• 실험식(Hill 표기법): C₃₂₄H₄₇₈N₉₄O₉₀S₈
• Molecular Weight: 7386.36
• MDL number: MFCD04119124
• UNSPSC 코드: 12352202
• NACRES: NA.32

속성

• 양식: solid
• Quality Level: 200
• 배송 상태: dry ice
• 저장 온도: −20°C
• 유전자 정보: human ... CACNA1G(8913), CACNA1H(8912), CACNA1I(8911) ; mouse ... CACNA1G(12291), CACNA1H(58226), CACNA1I(239556) ; rat ... CACNA1G(29717), CACNA1H(114862), CACNA1I(56827)

설명

Amino Acid Sequence

Lys-Ile-Asp-Gly-Tyr-Pro-Val-Asp-Tyr-Trp-Asn-Cys-Lys-Arg-Ile-Cys-Trp-Tyr-Asn-Asn-Lys-Tyr-Cys-Asn-Asp-Leu-Cys-Lys-Gly-Leu-Lys-Ala-Asp-Ser-Gly-Tyr-Cys-Trp-Gly-Trp-Thr-Leu-Ser-Cys-Tyr-Cys-Gln-Gly-Leu-Pro-Asp-Asn-Ala-Arg-Ile-Lys-Arg-Ser-Gly-Arg-Cys-Arg-Ala

일반 설명

Kurtoxin is hydrophobic in nature and shares sequence identity with α-scorpion and has cysteine-stabilized α-helix and β-sheet (CSαβ) motif. It interacts with N-type, and P-type calcium (Ca²⁺) channels as well.

애플리케이션

Kurtoxin has been used as a blocker of T-type and R-Type voltage-gated calcium channels (VGGCs) in hippocampal neurons.

생화학적/생리학적 작용

Kurtoxin is isolated from the venom of the South African scorpion Parabuthus transvaalicus. It associates with voltage-gated sodium channels and delays their inactivation.

T-type Ca²⁺ channel blocker; Scorpion toxin

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)