K2015

K-252a

Ready Made Solution, from Nonomuraea longicatena, >98%

• 동의어(들): SF 2370
• 실험식(Hill 표기법): C₂₇H₂₁N₃O₅
• CAS Number: 99533-80-9
• Molecular Weight: 467.47
• EC Number: 200-664-3
• MDL number: MFCD00161522
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329817131
• NACRES: NA.77

속성

• 생물학적 소스: Nonomuraea longicatena
• Quality Level: 200
• 분석: >98%
• 양식: solution
• 배송 상태: dry ice
• 저장 온도: −20°C
• SMILES string: [H][C@]12C[C@](O)(C(=O)OC)[C@](C)(O1)n3c4ccccc4c5c6CNC(=O)c6c7c8ccccc8n2c7c35
• InChI: 1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)/t18-,26+,27+/m1/s1
• InChI key: KOZFSFOOLUUIGY-SOLYNIJKSA-N
• 유전자 정보: human ... NTRK1(4914) ; rat ... Prkca(24680)

설명

생화학적/생리학적 작용

K-252a is also a specific inhibitor of Trk (tyrosine kinase) receptors and selectively blocks the effect of nerve growth factor. At lower concentrations, K-252a acts as a neuroprotective compound prompting survival of primary neuronal cultures. K-252a induces cell cycle arrest and apoptosis by inhibiting both Cdc2 and Cdc25c. K-252a improves psoriasis in a SCID mouse-human skin model and also suppresses referred mechanical hypersensitivity and neuropeptide up-regulation associated with acute pancreatitis.

특징 및 장점

This compound is featured on the Met and PKC pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

물리적 형태

Supplied as a 0.2 μm-filtered 1 mM solution in dimethyl sulfoxide (DMSO).

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): 188.6 °F - closed cup
• Flash Point (°C): 87 °C - closed cup
• 개인 보호 장비: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)