K3518

PIM2, active, GST tagged human

PRECISIO^® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

• UNSPSC 코드: 51111800
• NACRES: NA.32

속성

• 재조합: expressed in baculovirus infected Sf9 cells
• Quality Level: 200
• 제품 라인: PRECISIO^® Kinase
• 분석: ≥70% (SDS-PAGE)
• 양식: buffered aqueous glycerol solution
• 특이 활성도: 259-351 nmol/min·mg
• 분자량: ~61 kDa
• UniProt 수납 번호: Q9P1W9
• 배송 상태: dry ice
• 저장 온도: −70°C
• 유전자 정보: human ... PIM2(11040)

설명

애플리케이션

PIM2, active, GST tagged human has been used for in vitro kinase assay in study of PIM kinases role in fms-like tyrosine kinase 3 inhibitors (FLT3i)-resistant acute myeloid leukemia.

생화학적/생리학적 작용

PIM2 (proto-oncogene) is a serine threonine kinase that is present in all tissues, being most abundant in hematopoietic tissues, testis, small instestine and colon, as well as in spleen and thymus. It is highly expressed in human leukemic, lymphoma and colorectal adenocarcinoma cell lines. This suggests a role for PIM2 in proliferating cells and during meiosis. PIM2 acts as a pro-survival kinase and BAD (BCL2 associated agonist of cell death) protein is a PIM2 substrate.

물리적 형태

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

법적 정보

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)