콘텐츠로 건너뛰기
Merck
모든 사진(1)

주요 문서

L9545

Sigma-Aldrich

Leukemia Inhibitory Factor human, animal component free

recombinant, expressed in rice, 500 μg/mL

동의어(들):

Leukemia Inhibitory Factor human, LIF, rLIF

로그인조직 및 계약 가격 보기


About This Item

MDL number:
UNSPSC 코드:
12352202
NACRES:
NA.32

재조합

expressed in rice

분석

>95% (SDS-PAGE)

효능

>1 x 108 units/mg ED<sub>50</sub>

농도

500 μg/mL

기술

cell culture | mammalian: suitable

불순물

<0.05 EU/μg endotoxin

UniProt 수납 번호

배송 상태

dry ice

저장 온도

−70°C

유전자 정보

human ... LIF(3976)

유사한 제품을 찾으십니까? 방문 제품 비교 안내

생화학적/생리학적 작용

Leukemia Inhibitory Factor (LIF) is a pleiotropic glycoprotein originally described to inhibit the proliferation of the murine myeloid leukemic cell line M1, while inducing differentiation into macrophages. Other activities were later identified to LIF, which is known by a variety of synonyms, including DIF, D-factor, DIA, DRF, CNDF, HILDA, HSF-III, and MLPLI. Human LIF exerts its actions through a receptor comprising a 190 kDa LIF-binding α-chain (130 kDa, mouse) and a 130 kDa signal-transducing β-chain (gp130), which is shared with CNTF, OSM, L-6 and IL-11. As such, it is a member of the gp130 family of the cytokine receptor superfamily. LIF receptors have been identified on several cells, including monocytes, liver, placenta and embryonic stem cells. Natural LIF is heavily glycosylated, showing an apparent molecular weight of 32 kDa to 62 kDa, depending on the source, but absence of glycosylation appears not to affect its biological activity. A single gene encodes LIF, which is secreted as a single chain glycoprotein containing 180 amino acids for human or mouse with a conserved disulfide bond. Human and mouse LIF share 78% sequence homology. Human LIF can activate mouse cells, but mouse LIF cannot activate human cells.
Leukemia Inhibitory Factor (LIF) is a pleiotropic glycoprotein that inhibits the proliferation of the murine myeloid leukemic cell line M1, while inducing differentiation into macrophages. Human and mouse LIF share 78% sequence homology. Human LIF can activate mouse cells, but mouse LIF cannot activate human cells.

물리적 형태

0.2 μm filtered solution at 500 μg/mL in buffered saline with 0.02% TWEEN20

기타 정보

rhLeukemia Inhibitory Factor manufactured in the USA by InVitria.

Storage Class Code

10 - Combustible liquids

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number

적합한 버전을 찾을 수 없으신가요?

특정 버전이 필요한 경우 로트 번호나 배치 번호로 특정 인증서를 찾을 수 있습니다.

이 제품을 이미 가지고 계십니까?

문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..

고객지원팀으로 연락바랍니다.