L9908
LY-294,002 hydrochloride
from microbial (Staphylococcus roseus), ≥98% (HPLC), solid, PI3K inhibitor
동의어(들):
2-(4-Morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride
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모든 사진(4)
About This Item
실험식(Hill 표기법):
C19H17NO3 · HCl
CAS Number:
Molecular Weight:
343.80
MDL number:
UNSPSC 코드:
12352207
PubChem Substance ID:
NACRES:
NA.77
추천 제품
Product Name
LY-294,002 hydrochloride, solid, ≥98% (HPLC)
생물학적 소스
microbial (Staphylococcus roseus)
Quality Level
분석
≥98% (HPLC)
양식
solid
색상
white to off-white
solubility
DMSO: >5 mg/mL
H2O: insoluble
저장 온도
2-8°C
SMILES string
O=C1C=C(Oc2c1cccc2-c3ccccc3)N4CCOCC4
InChI
1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2
InChI key
CZQHHVNHHHRRDU-UHFFFAOYSA-N
관련 카테고리
일반 설명
LY-294,002 hydrochloride is a derivative of the flavonoid, quercetin and elicits higher inhibition on the enzyme phosphoinositide 3-kinase (PI3K). LY-294,002 inhibits nuclear factor kappa B signaling in macrophages. It elevates expression of autophagosomal protein LC3 and promotes apoptosis in gastric and nasopharyngeal cancer cells. LY-294,002 modulates action potential repolarization and improves myocyte contractility.
애플리케이션
LY-294,002 hydrochloride has been used in the inhibition of:
- phosphoinositide 3-kinase (PI3K) in human lung cancer cell line
- autophagy in mesenchymal stem cells (MSCs).
- serine/threonine-specific protein kinase (AKT) signaling in fibroblasts and cardiac cells.
생화학적/생리학적 작용
Specific cell permeable phosphatidylinositol 3-kinase inhibitor.
특징 및 장점
This compound is a featured product for Cyclic Nucleotide and Kinase Phosphatase Biology research. Discover more featured Cyclic Nucleotide and Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the G Proteins (Heterotrimeric) and Phosphoinositide Kinases pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
이미 열람한 고객
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