M2070

Merbarone

≥98% (HPLC), solid

• 동의어(들): 5-(N-Phenylcarbamoyl)-2-thiobarbituric acid, NSC-336628
• 실험식(Hill 표기법): C₁₁H₉N₃O₃S
• CAS Number: 97534-21-9
• Molecular Weight: 263.27
• MDL number: MFCD00866337
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24724534
• NACRES: NA.77

속성

• 분석: ≥98% (HPLC)
• 양식: solid
• 약물 제어: regulated under CDSA - not available from Sigma-Aldrich Canada
• solubility: DMSO: >5 mg/mL
• 저장 온도: 2-8°C
• SMILES string: O=C1NC(=S)NC(=O)C1C(=O)Nc2ccccc2
• InChI: 1S/C11H9N3O3S/c15-8(12-6-4-2-1-3-5-6)7-9(16)13-11(18)14-10(7)17/h1-5,7H,(H,12,15)(H2,13,14,16,17,18)
• InChI key: JARCFMKMOFFIGZ-UHFFFAOYSA-N

설명

애플리케이션

Merbarone has been used to study its effect on the occurrence of DNA lesions.

생화학적/생리학적 작용

Selective topoisomerase II inhibitor. Blocks topo II-mediated DNA cleavage without stabilizing DNA-topo II-cleavable complexes. Induces apoptosis in CEM cells via caspase 3 dependent mechanism.

Thiobarbituric acid with aniline joined by an amide linkage forms merbarone. It is known to prolong cell cycle progression by inducing DNA double strand breaks, retarding S phase and arresting G2 phase. This delays cell entry into mitosis. Merbarone possesses cytotoxic and genotoxic action and promotes endoreduplication. Merbarone has mild antitumor action and is also found to nephrotoxic.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)