M7068

MPP dihydrochloride hydrate

≥97% (HPLC), powder, estrogen receptor α agonist

• 동의어(들): 1,3-Bis(4-hydroxyphenyl)-4-methyl-5-[4-(2-piperidinylethoxy)phenol]-1H-pyrazole dihydrochloride hydrate, Methyl-piperidino-pyrazole hydrate
• 실험식(Hill 표기법): C₂₉H₃₁N₃O₃ · 2 HCl · xH₂O
• CAS Number: 911295-24-4
• Molecular Weight: 542.50 (anhydrous basis)
• MDL number: MFCD06411603
• UNSPSC 코드: 51111800
• PubChem Substance ID: 24724540
• NACRES: NA.77

속성

• Product Name: MPP dihydrochloride hydrate, ≥97% (HPLC), white, powder
• Quality Level: 100
• 분석: ≥97% (HPLC)
• 양식: powder
• 저장 조건: desiccated
• 색상: white
• solubility: DMSO: soluble ≥20 mg/mL
• SMILES string: Cl.Cl.Cc1c(nn(-c2ccc(O)cc2)c1-c3ccc(OCCN4CCCCC4)cc3)-c5ccc(O)cc5
• InChI: 1S/C29H31N3O3.2ClH/c1-21-28(22-5-11-25(33)12-6-22)30-32(24-9-13-26(34)14-10-24)29(21)23-7-15-27(16-8-23)35-20-19-31-17-3-2-4-18-31;;/h5-16,33-34H,2-4,17-20H2,1H3;2*1H
• InChI key: FWDNPWVVRVSJQH-UHFFFAOYSA-N

설명

일반 설명

Methyl-piperidino-pyrazole hydrate (MPP) is prepared from a methyl-pyrazole-triol (MPT), a pyrazole triol.

애플리케이션

MPP dihydrochloride hydrate has been used as an estrogen receptor α antagonist:

• in human breast cancer MCF-7 cells
• to pre-treat endometrial ex vivo organ cultures (EVOCs)
• to treat pituitary glands to monitor luteinizing hormone secretion

생화학적/생리학적 작용

MPP dihydrochloride is a specific estrogen receptor α antagonist.

Methyl-piperidino-pyrazole hydrate (MPP) is an agonist for estrogen receptor α and lacks any ligand functionality with estrogen receptor (ER)β. It promotes silibinin induced apoptosis in human breast cancer MCF-7 cells.

Specific estrogen receptor α antagonist.

기타 정보

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves