M8699

(R)-MG132

• 동의어(들): Z-L-Leu-D-Leu-L-Leu-al
• 실험식(Hill 표기법): C₂₆H₄₁N₃O₅
• CAS Number: 1211877-36-9
• Molecular Weight: 475.62
• UNSPSC 코드: 12352200
• NACRES: NA.32

속성

• 분석: ≥98%
• Quality Level: 200
• solubility: DMSO or DMF: 25 mg/mL
• 저장 온도: −20°C
• SMILES string: CC(C)C[C@@H](C(N[C@H](C(N[C@H](C=O)CC(C)C)=O)CC(C)C)=O)NC(OCC1=CC=CC=C1)=O
• InChI: 1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22-,23-/m0/s1
• InChI key: TZYWCYJVHRLUCT-VABKMULXSA-N

설명

애플리케이션

(R)-MG132 has been used in ubiquitination assay and is used as a proteasome inhibitor.

생화학적/생리학적 작용

MG132 (carbobenzoxy-Leu-Leu-leucinal) is a tri-peptide aldehyde. It possesses antitumor activity and boosts cytostatic/cytotoxic effects of chemo- and radiotherapy. (R)-MG132 is a potent, membrane-permeable proteasome inhibitor. It can inhibit proteasome activity in lysates of J558L multiple myeloma cells and EMT6 breast cancer cells. The (R)-MG132 stereoisomer is a more effective inhibitor of chymotrypsin-like (ChTL), trypsin-like (TL), and peptidylglutamyl peptide hydrolyzing proteasome (PGPH) activities than the (S)-MG132.

물리적 형태

crystalline solid or supercooled liquid

기타 정보

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable