M9440

Methyl-3,4-dephostatin

>98% (HPLC), powder

• 동의어(들): 3,4-Dihydroxy-N-methyl-N-nitrosoaniline
• 실험식(Hill 표기법): C₇H₈N₂O₃
• CAS Number: 173043-84-0
• Molecular Weight: 168.15
• MDL number: MFCD01076450
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24278575
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: >98% (HPLC)
• 양식: powder
• 색상: red-brown
• solubility: DMSO: soluble 18 mg/mL; H₂O: insoluble
• 저장 온도: 2-8°C
• SMILES string: CN(N=O)c1ccc(O)c(O)c1
• InChI: 1S/C7H8N2O3/c1-9(8-12)5-2-3-6(10)7(11)4-5/h2-4,10-11H,1H3
• InChI key: XAKAQCMEMMZUEO-UHFFFAOYSA-N
• 유전자 정보: human ... PTPN1(5770)

설명

애플리케이션

Methyl-3,4-dephostatin has been used as:

• an inhibitor for methyltransferases
• a kinase-related inhibitor for human transglutaminase
• a cysteine binding compound for screening its effect on C-terminal domain (CTD) of human immunodeficiency virus (HIV-1) capsid protein

생화학적/생리학적 작용

Methyl-3,4-dephostatin is a tyrphostin-related compound isolated from Streptomyces MJ742-NF5 strain. It favors nerve growth factor-based neurite formation in pheochromocytoma PC12 cells. Being a stable analog of the nitrosoaniline dephostatin, it can mimic phosphotyrosine substrate for Tyrosyl-DNA phosphodiesterase I (TdpI).

Stable analog of dephostatin; selective protein tyrosine phosphatase 1B and SHPTP-1 inhibitor; does not inhibit CD45-associated phosphatases.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)