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Merck
모든 사진(1)

주요 문서

MSST0022

Sigma-Aldrich

SILuLite CRP C-reactive Protein human

recombinant, expressed in HEK 293 cells, MS Protein Standard

동의어(들):

PTX1, pentaxin, pentraxin

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About This Item

UNSPSC 코드:
23201100
NACRES:
NA.12

생물학적 소스

human

Quality Level

재조합

expressed in HEK 293 cells

분석

≥98% (SDS-PAGE)

양식

liquid

기술

mass spectrometry (MS): suitable

적합성

suitable for mass spectrometry (internal calibrator)

UniProt 수납 번호

저장 온도

−20°C

유전자 정보

human ... PTX3(5806)

일반 설명

SILuLite CRP is a recombinant human protein expressed in human 293 cells. It is a protein consisting of 226 amino acids (including a C-terminal polyhistidine and FLAG® tags), with a calculated molecular weight of ~25 kDa. SILuLite CRP is an analytical standard designed to be used as starting material for preparation of calibrators and controls in LC-MS applications.


Suggested Quantitative Analysis Parameters
(MRM settings provided for three suggested peptides)

생화학적/생리학적 작용

CRP is a hepatically derived pentraxin. It exists mainly as a pentamer in a cyclic structure with 5 identical 23-kD subunits in the blood. In addition to its role as an "acute phase" protein or first-line defense molecule against pathogenic organisms, baseline levels of CRP correlate positively to adverse cardiovascular events. CRP is therefore being considered a “risk factor” for cardiovascular disease. In humans, treatment with statin therapy reduces levels of both LDL-C and CRP, and concurrently there is a reduction in the number of cardiovascular events. A recent study suggests that patients with elevated basal levels of CRP are at an increased risk of diabetes, in addition to cardiovascular disease. A study of over 700 nurses showed that those in the highest quartile of trans fat consumption had blood levels of CRP that were 73% higher than those in the lowest quartile.

서열

QTDMSRKAFVFPKESDTSYVSLKAPLTKPLKAFTVCLHFYTELSSTRGYSIFSYATKRQDNEILIFWSKDIGYSFTVGGSEILFEVPEVTVAPVHICTSWESASGIVEFWVDGKPRVRKSLKKGYTVGAEASIILGQEQDSFGGNFEGSQSLVGDIGNVNMWDFVLSPDEINTIYLGGPFSPNVLNWRALKYEVQGEVFTKPQLWPDYKDDDDKGHHHHHHHHGGQ

물리적 형태

Supplied as a solution of phosphate buffered saline with 25% glycerol.

법적 정보

FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany
SILu is a trademark of Sigma-Aldrich Co. LLC

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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