MTOX1301

Canine MDR1 Knockout MDCKII Control Cells

canine kidney (cocker spaniel)

• 동의어(들): MDCKII MDR1 KO
• UNSPSC 코드: 12352207
• NACRES: NA.24

속성

• Product Name: Canine MDR1 Knockout MDCKII Control Cells,
• 생물학적 소스: canine kidney (cocker spaniel)
• Quality Level: 200
• 양식: liquid
• 저장 온도: −196°C

설명

애플리케이션

See technical bulletin for detailed protocols

특징 및 장점

MDCK II - Madin-Darby canine kidney- is a subclone derived from the heterogenous parent line - MDCK (ECACC catalogue no. 85011435) MDCK II cells, which predominate in later passages from MDCK, are reported to display electrical resistance of 100 ohm/cm2. This strain is thought to be derived from the distal tubule or collecting duct of the nephron. The cell line can be used as an experimental model to study the generation and maintenance of cell surface polarity in epithelial cells.

The canine MDR1 (cP-gp) efflux transporter gene has been effectively disrupted in both alleles. There is no expression of the cP-gp. Validation studies have shown no efflux of standard cP-gp substrates.

품질

Tested for Mycoplasma, sterility, post-freeze viability, short terminal repeat (STR) analysis for cell line identification.

법적 정보

Exhibit 1: ADME/Tox cell lines licenseMDCKII subclone was originally isolated by Daniel Louvard, Institut Curie, Paris France.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable