N0289

Nafamostat mesylate

≥98% (HPLC), powder, serine protease inhibitor

• 동의어(들): 4-[(Aminoiminomethyl)amino]benzoic acid 6-(aminoiminomethyl)-2-naphthalenyl ester dimethanesulfonate, FUT-175
• 실험식(Hill 표기법): C₁₉H₁₇N₅O₂ · 2CH₄O₃S
• CAS Number: 82956-11-4
• Molecular Weight: 539.58
• MDL number: MFCD00941430
• UNSPSC 코드: 51111800
• PubChem Substance ID: 329818423
• NACRES: NA.77

속성

• Product Name: Nafamostat mesylate, ≥98% (HPLC)
• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 10 mg/mL, clear; H₂O: >10 mg/mL
• 저장 온도: room temp
• SMILES string: CS(O)(=O)=O.CS(O)(=O)=O.NC(=N)Nc1ccc(cc1)C(=O)Oc2ccc3cc(ccc3c2)C(N)=N
• InChI: 1S/C19H17N5O2.2CH4O3S/c20-17(21)14-2-1-13-10-16(8-5-12(13)9-14)26-18(25)11-3-6-15(7-4-11)24-19(22)23;2*1-5(2,3)4/h1-10H,(H3,20,21)(H4,22,23,24);2*1H3,(H,2,3,4)
• InChI key: SRXKIZXIRHMPFW-UHFFFAOYSA-N

설명

애플리케이션

Nafamostat mesylate has been used:

• as a serine protease inhibitor to study its effects on proteolytic degradation of therapeutic proteins recombinantly expressed in Chinese hamster ovary (CHO)-K1-derived cells
• to stop complement activation to validate the assay for murine C3 fragments
• as a serine protease inhibitor to study its effects on house dust mite extract evoked Ca²⁺ entry

생화학적/생리학적 작용

Nafamostat mesylate is a broad spectrum serine protease inhibitor, kallikrein inhibitor, and inhibits blood coagulation.

Nafamostat mesylate is a broad spectrum serine protease inhibitor, kallikrein inhibitor, and inhibits blood coagulation. It is also a possible complement inhibitor.

Nafamostat mesylate is used in the treatment of disseminated intravascular coagulation (DIC), pancreatitis, and systemic inflammatory response syndrome. It can block the proliferation, adhesion, and invasion of cancer cells and repress tumor progression in animal models. Nafamostat mesylate is involved in the development of immune activity. In combination with favipiravir, nafamostat mesylate may block virus entry and replication, and inhibit the pathogenic host response. This combination treatment might be effective for critically ill Covid-19 patients.

안전성 정보

• 픽토그램: GHS08
• 신호어: Warning
• 유해 및 위험 성명서: H361fd
• 예방조치 성명서: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)