N0630

Niflumic acid

• 동의어(들): 2-(α,α,α-Trifluoro-m-toluidino)nicotinic acid, 2-[3-(Trifluoromethyl)anilino]nicotinic acid
• 실험식(Hill 표기법): C₁₃H₉F₃N₂O₂
• CAS Number: 4394-00-7
• Molecular Weight: 282.22
• EC Number: 224-516-2
• MDL number: MFCD00010569
• UNSPSC 코드: 12352106
• PubChem Substance ID: 24278582
• NACRES: NA.77

속성

• 생물학적 소스: synthetic (organic)
• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• mp: 203-204 °C
• solubility: acetone: 50 mg/mL, clear to slightly hazy, yellow
• SMILES string: O=C(O)C1=CC=CN=C1NC2=CC(C(F)(F)F)=CC=C2
• InChI: 1S/C13H9F3N2O2/c14-13(15,16)8-3-1-4-9(7-8)18-11-10(12(19)20)5-2-6-17-11/h1-7H,(H,17,18)(H,19,20)
• InChI key: JZFPYUNJRRFVQU-UHFFFAOYSA-N
• 유전자 정보: human ... PTGS1(5742)

설명

애플리케이션

Niflumic acid has been used:

• as a chloride channel blocker in mouse olfactory epithelium for odor-induced electroolfactograms (EOGs) measurements, to test its analgesic effect on rat dorsal root ganglion neurons post γ-aminobutyric acid induction
• as a calcium-activated chloride channel (CaCC) inhibitor in C2C12 myoblasts and also to test its effect on volume-regulated anion channel (VRAC)
• as an inhibitor of voltage-dependent potassium channel in human embryonic kidney (HEK 293) phoenix cells

생화학적/생리학적 작용

Niflumic acid (NFA), a γ-aminobutyric acid type A receptor (GABAARs) antagonist is a non-steroidal anti-inflammatory drug (NSAID) and it belongs to the fenamate class. It is also a blocker of chloride ion channel and a calcium-activated chloride channel (CaCC) inhibitor. NFA possesses anti-inflammatory property and is useful in treating rheumatic disorders. It is also an inhibitor of N-methyl-D-aspartate receptor and glycine receptor. NFA also inhibits enzymes associated with the prostaglandins synthesis.

Selective cyclooxygenase-2 (COX-2) inhibitor.

특징 및 장점

This compound is featured on the Chloride Channels and Potassium Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

안전성 정보

• 픽토그램: GHS06
• 신호어: Danger
• 유해 및 위험 성명서: H301,H413
• 예방조치 성명서: P264 - P270 - P273 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral - Aquatic Chronic 4
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Faceshields, Gloves