N0636

Nicotinamide

BioReagent, suitable for cell culture, suitable for insect cell culture

• 동의어(들): Niacinamide, Nicotinic acid amide, Pyridine-3-carboxylic acid amide, Vitamin B₃, Vitamin PP
• 실험식(Hill 표기법): C₆H₆N₂O
• CAS Number: 98-92-0
• Molecular Weight: 122.12
• Beilstein: 383619
• EC Number: 202-713-4
• MDL number: MFCD00006395
• UNSPSC 코드: 12352205
• PubChem Substance ID: 24897434
• NACRES: NA.75

속성

• 생물학적 소스: synthetic (organic)
• 제품 라인: BioReagent
• 분석: ≥98% (HPLC)
• 양식: powder
• 분자량: M_w 122.12 g/mol
• 기술: cell culture | insect: suitable; cell culture | mammalian: suitable
• 색상: white
• mp: 128-131 °C (lit.)
• solubility: water: soluble 50 mg/mL, clear, colorless
• SMILES string: NC(=O)c1cccnc1
• InChI: 1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)
• InChI key: DFPAKSUCGFBDDF-UHFFFAOYSA-N
• 유전자 정보: human ... PARP1(142), SIRT2(22933)

설명

일반 설명

Nicotinamide (NAM) belongs to vitamin B family and is the amide form of vitamin B3. NAM is present in food and is a constituent of nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP). Tryptophan is the precursor for NAM synthesis in liver. NAM controls cell metabolism, redox reactions, mitochondrial functionsand energy generation. It promotes natural killer cells proliferation and survival. NAM confers neuroprotection and promotes neuronal maturation. It has the ability to cross the blood-brain barrier and may provide protection in ischaemic stroke and traumatic brain injury. NAM may elicit therapeutic benefits in Alzheimer′s, Parkinson′s, and Huntington′s diseases.

애플리케이션

Nicotinamide has been used as a medium supplement in organoid culture of intestinal stem cells, esophageal squamous cell carcinomas(ESCC), pancreatic cancer organoids and pancreatic progenitor induction.

생화학적/생리학적 작용

Nicotinamide is an amide derivative of vitamin B3 and a PARP inhibitor

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H319
• 예방조치 성명서: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Eye Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): 302.0 °F - closed cup
• Flash Point (°C): 150 °C - closed cup
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves