N1538

Nobiletin

≥97%

• 동의어(들): 2-(3,4-Dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one, 3′,4′,5,6,7,8-Hexamethoxyflavone
• 실험식(Hill 표기법): C₂₁H₂₂O₈
• CAS Number: 478-01-3
• Molecular Weight: 402.39
• Beilstein: 360887
• MDL number: MFCD03273560
• UNSPSC 코드: 12352205
• PubChem Substance ID: 329818583
• NACRES: NA.25

속성

• Quality Level: 100
• 분석: ≥97%
• 양식: powder
• 저장 온도: −20°C
• SMILES string: COc1ccc(cc1OC)C2=CC(=O)c3c(OC)c(OC)c(OC)c(OC)c3O2
• InChI: 1S/C21H22O8/c1-23-13-8-7-11(9-15(13)24-2)14-10-12(22)16-17(25-3)19(26-4)21(28-6)20(27-5)18(16)29-14/h7-10H,1-6H3
• InChI key: MRIAQLRQZPPODS-UHFFFAOYSA-N

설명

애플리케이션

• Nobiletin as a novel agent to enhance porcine in vitro embryo development and quality: This study explores the potential of nobiletin to improve embryo development and quality in porcine models, providing insights into its applications in reproductive biotechnology and animal science (Cajas YN, Martinez-Serrano CA, 2024 Apr 22) (source).


• Nobiletin alleviates cisplatin-induced ototoxicity: Research indicates that nobiletin can mitigate the ototoxic effects of cisplatin chemotherapy by activating autophagy and inhibiting ferroptosis, suggesting a new therapeutic avenue for protecting auditory health during cancer treatment (Song W, Lu Z, 2024 Apr 3) (source).


• Nobiletin targets SREBP1/ACLY to induce autophagy-dependent cell death of gastric cancer cells: This study reveals that nobiletin promotes autophagy-dependent cell death in gastric cancer cells by targeting the SREBP1/ACLY axis within the PI3K/Akt/mTOR signaling pathway, proposing a novel anticancer strategy (Chen M, Sun Q, 2024 Jun) (source).


• Recent advances in the therapeutic potential of nobiletin against respiratory diseases: A comprehensive review on the therapeutic applications of nobiletin in treating respiratory diseases, emphasizing its anti-inflammatory and antioxidant properties as mechanisms for intervention (Qin Y, Li J, 2024 Jun) (source).

생화학적/생리학적 작용

Nobiletin suppresses the expression of matrix metalloproteinases 1, 3 and 9, which participate in the break down of the extracellular matrix during tumor metastasis. Nobiletin is also involved in the increased expression of tissue inhibitor of matrix metalloproteinase 1 further preventing extracellular matrix degradation during tumor invasion. This bioflavonoid is believed to achieve both of these functions by disrupting the signal transduction pathway of Ras-Raf-MEK.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable