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Merck
모든 사진(1)

주요 문서

N2787

Sigma-Aldrich

Monoclonal Anti-Neurofilament 160 antibody produced in mouse

~2 mg/mL, clone RMO44, purified immunoglobulin, buffered aqueous solution

동의어(들):

Anti-Neurofilament Medium Chain

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About This Item

MDL number:
UNSPSC 코드:
12352203
NACRES:
NA.41

생물학적 소스

mouse

Quality Level

결합

unconjugated

항체 형태

purified immunoglobulin

항체 생산 유형

primary antibodies

클론

RMO44, monoclonal

양식

buffered aqueous solution

종 반응성

human, mouse, rat, zebrafish

농도

~2 mg/mL

기술

immunohistochemistry: suitable
microarray: suitable
western blot: 1-2 μg/mL using extract of SHSy5y human neuroblastoma cells

동형

IgG1

UniProt 수납 번호

배송 상태

dry ice

저장 온도

−20°C

타겟 번역 후 변형

unmodified

유전자 정보

human ... NEFM(4741)
mouse ... Nefm(18040)
rat ... Nefm(24588)

일반 설명

Monoclonal Anti- Neurofilament 160 (mouse IgG1 isotype) is derived from the hybridoma RMO44 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with purified mid-sized rat neurofilament (NF-M) subunit. Neurofilaments are one of the five major groups of intermediate filaments (Ifs) and are found predominantly in cells or tissues of neuronal origin. They are composed of three major proteins of apparent molecular weights 68 kDa, 160 kDa and 200 kDa.
Neurofilament 160 (NEFM) is one among the most abundant filaments in post-mitotic neurons.

면역원

purified mid-sized rat neurofilament (NF-M) subunit.

애플리케이션

Monoclonal Anti-Neurofilament 160 antibody produced in mouse has been used in:
  • enzyme-linked immunosorbent assay (ELISA)
  • western blot analysis
  • immunohistochemistry
  • antibody labelling

생화학적/생리학적 작용

Neurofilament 160 (NEFM) associates with the dopamine receptor.
Neurofilament proteins are synthesized in the neuronal perikarya, assembled to form filaments and then slowly transported within the axons towards the synaptic terminals. These molecules undergo post-translational modifications, which results in their heterogeneity including different levels of phosphorylation. The phosphorylation of neurofilament polypeptides has been suggested to modulate their function by influencing their interaction with cytoplasmic organelles.

물리적 형태

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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