N4773

Neuron-specific enolase from human brain

≥95% (SDS-PAGE), buffered aqueous solution

• 동의어(들): 2-Phospho-D-glycerate hydro-lyase, Enolase, Neuron-specific from human brain, NSE, Thermolabile antigen A
• EC 번호: 4.2.1.11 (BRENDA, IUBMB)
• MDL number: MFCD00081785
• UNSPSC 코드: 12352204
• NACRES: NA.54

속성

• 생물학적 소스: human brain
• Quality Level: 200
• 분석: ≥95% (SDS-PAGE)
• 양식: buffered aqueous solution
• 특이 활성도: ≥10 units/mg protein
• UniProt 수납 번호: P09104
• 배송 상태: dry ice
• 저장 온도: −20°C
• 유전자 정보: human ... ENO2(2026)

설명

일반 설명

Neuron-specific enolase (NSE) is a neuronal form of the glycolytic enzyme enolase, which was first found in extracts of brain tissue.

애플리케이션

Neuron-specific enolase from human brain has been used in a study to assess human amniotic mesenchymal stem cells in the treatment of focal cerebral ischemia. It has also been used in a study to investigate sinonasal teratocarcinosarcoma with rhabdoid features.

생화학적/생리학적 작용

Neuron-specific enolase (NSE) is expressed in all neuronal cell types, and its expression marks the acquisition of synaptic function. Following acute neuronal injury, NSE levels are increased in neuronal cell bodies. Increased levels of NSE in serum and cerebrospinal fluid have been used as markers for injury and neuronal cell death. Tumors derived from many cell types, including most neuronal and neuroendocrine tumors, express NSE.

Neuron-specific enolase promotes survival of neurons and can provide neuroprotective effects by binding to neurons in a calcium-dependent manner.

단위 정의

One unit causes the formation of 1.0 μmole of phospho(enol)pyruvate per minute at pH 6.8 at 25 °C

물리적 형태

Solution in 100 mM Tris-HCl, 5 mM MgSO₄, 250 mM KCl, pH 5.0-5.2

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable