O4000

Oxythiamine chloride hydrochloride

≥95% (HPLC)

• 동의어(들): 5-(2-Hydroxyethyl)-3-(4-hydroxy-2-methyl-5-pyrimidinylmethyl)-4-methylthiazolium chloride
• 실험식(Hill 표기법): C₁₂H₁₆ClN₃O₂S · HCl
• CAS Number: 614-05-1
• Molecular Weight: 338.25
• MDL number: MFCD00050656
• UNSPSC 코드: 12352116
• PubChem Substance ID: 24897990
• NACRES: NA.79

속성

• Quality Level: 200
• 분석: ≥95% (HPLC)
• 양식: powder
• 기술: HPLC: suitable
• 색상: white to off-white
• 저장 온도: −20°C
• SMILES string: CC(N1)=NC=C(C[N+]2=CSC(CCO)=C2C)C1=O.Cl.[Cl-]
• InChI: 1S/C12H16N3O2S.2ClH/c1-8-11(3-4-16)18-7-15(8)6-10-5-13-9(2)14-12(10)17;;/h5,7,16H,3-4,6H2,1-2H3,(H,13,14,17);2*1H
• InChI key: QHUYPZVMEJLSEB-UHFFFAOYSA-N

설명

일반 설명

Oxythiamine is a thiamine antimetabolite and the source through diet is by consuming acidic thiamine rich foods.

애플리케이션

Oxythiamine chloride hydrochloride is suitable for use:

• as a reference standard for calibration curve generation in liquid chromatography-tandem mass spectrometry (LC-MS/MS) for oxythiamine pyrophosphate (OTPP) quantification in red blood cells
• as a thiamine transport inhibitor in human mammary epithelial cells (HMEC) and breast cancer cell lines
• in the synthesis of oxythiamineH picrolonate salt

생화학적/생리학적 작용

Oxythiamine (OT) is a thiamine antagonist. It is a transketolase inhibitor and is employed to study anti-metastatic mechanisms, especially those involving metalloproteinases (MMP). It significantly sensitizes human hepatocellular carcinoma cells (HCC) to sorafenib, favoring tumor suppression.

Oxythiamine inhibits Transketolase, the enzyme that controls the nonoxidative branch of the pentose phosphate pathway.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)