O4139

Orlistat

≥98% (HPLC), solid, lipase inhibitor

• 동의어(들): (−)-Tetrahydrolipstatin, N-Formyl-L-leucine (1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester, Ro-18-0647
• 실험식(Hill 표기법): C₂₉H₅₃NO₅
• CAS Number: 96829-58-2
• Molecular Weight: 495.73
• MDL number: MFCD05662360
• UNSPSC 코드: 41106300
• PubChem Substance ID: 24724564
• NACRES: NA.77

속성

• Product Name: Orlistat, ≥98%, solid
• 생물학적 소스: synthetic (organic)
• Quality Level: 200
• 분석: ≥98%
• 양식: solid
• 색상: white
• mp: <50 °C
• solubility: DMSO: 19 mg/mL
• 주관자: Roche
• 저장 온도: 2-8°C
• SMILES string: CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](CC(C)C)NC=O
• InChI: 1S/C29H53NO5/c1-5-7-9-11-12-13-14-15-16-18-24(34-29(33)26(30-22-31)20-23(3)4)21-27-25(28(32)35-27)19-17-10-8-6-2/h22-27H,5-21H2,1-4H3,(H,30,31)/t24-,25-,26-,27-/m0/s1
• InChI key: AHLBNYSZXLDEJQ-FWEHEUNISA-N
• 유전자 정보: human ... LIPF(8513), PNLIP(5406)

설명

일반 설명

Orlistat acts as a gastric lipase inhibitor that reduces fat absorption.

애플리케이션

Orlistat has been used as an inhibitor:

• of fatty acid synthase in long-term estrogen-deprived (LTED) variant cell lines
• of lipase in screening lipase inhibition by raspberry extract
• in in vitro pancreatic lipase activity assay

생화학적/생리학적 작용

Orlistat impairs intestinal fat absorption and is effective in weight management. It is regarded as a safe drug for treating obesity. It delays the progression of type 2 diabetes mellitus especially in obese and improves glycemic parameters. Long term usage of orlistat results in improved weight reduction and it may not contribute in colorectal carcinogenesis.

Orlistat, used in obesity research, is a pancreatic lipase inhibitor that acts locally in the gastrointestinal tract to inhibit lipase.

특징 및 장점

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

기타 정보

Solution is not completely clear, small particles may remain floating.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)