O8757

Ofloxacin

fluoroquinolone antibiotic

• 동의어(들): Dextrofloxacin
• 실험식(Hill 표기법): C₁₈H₂₀FN₃O₄
• CAS Number: 82419-36-1
• Molecular Weight: 361.37
• MDL number: MFCD00226105
• UNSPSC 코드: 51282956
• PubChem Substance ID: 24278613
• NACRES: NA.76

속성

• 생물학적 소스: synthetic
• Quality Level: 200
• 분석: ≥99% (HPLC)
• 양식: powder
• solubility: 1 M NaOH: soluble 50 mg/mL
• 항생제 활성 스펙트럼: Gram-negative bacteria; Gram-positive bacteria; mycobacteria
• 동작 모드: DNA synthesis | interferes; enzyme | inhibits
• 저장 온도: 2-8°C
• SMILES string: FC1=C(C3=[c]4[n](cc([c]([c]4=C1)=O)C(=O)O)C(CO3)C)N2CCN(CC2)C
• InChI: 1S/C18H20FN3O4/c1-10-9-26-17-14-11(16(23)12(18(24)25)8-22(10)14)7-13(19)15(17)21-5-3-20(2)4-6-21/h7-8,10H,3-6,9H2,1-2H3,(H,24,25)
• InChI key: GSDSWSVVBLHKDQ-UHFFFAOYSA-N
• 유전자 정보: human ... CSNK2A1(1457), KCNH1(3756) ; rat ... Gabra1(29705)

설명

일반 설명

Chemical structure: fluoroquinolone

애플리케이션

Ofloxacin is a synthetic fluoroquinolone with broad-spectrum antibacterial activity. It is a nalidixic acid analog. It is given to patients before undergoing retinal reattachment surgery.

생화학적/생리학적 작용

Ofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, which haults DNA replication and cell division. Ofloxacin has been shown to convert LytA from the inactive E-form to the active C-form. It is a chiral molecule that inhibits pneumococcal cell wall-degrading virulence factors.

기타 정보

Keep container tightly closed in a dry and well-ventilated place.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)