P6124

5-(4-Phenoxybutoxy)psoralen

≥98% (HPLC), solid

• 동의어(들): PAP-1
• 실험식(Hill 표기법): C₂₁H₁₈O₅
• CAS Number: 870653-45-5
• Molecular Weight: 350.36
• MDL number: MFCD11114059
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24724583
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: solid
• 저장 조건: protect from light
• 색상: white
• solubility: DMSO: 9 mg/mL
• 저장 온도: 2-8°C
• SMILES string: O=C1Oc2cc3occc3c(OCCCCOc4ccccc4)c2C=C1
• InChI: 1S/C21H18O5/c22-20-9-8-16-19(26-20)14-18-17(10-13-24-18)21(16)25-12-5-4-11-23-15-6-2-1-3-7-15/h1-3,6-10,13-14H,4-5,11-12H2
• InChI key: KINMYBBFQRSVLL-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

5-(4-Phenoxybutoxy)psoralen (PAP-1) is derived from 5-methoxypsoralen, a natural compound. PAP-1 show higher selectivity for Kv1.3 (voltage-gated potassium channels) than other Kv1 family members. Kv1.3 is predominant on cell membranes of activated effector memory T-cells. Inhibition of Kv1.3 results in membrane depolarization. In rat models, PAP-1 is known to delay the onset of diabetes. It might be used in the treatment of psoriasis and effector memory T cells mediated autoimmune diseases. Oral, intraperitoneal and topical administration of PAP-1 prevents allergic contact dermatitis induced by oxazolone.

Selective inhibitor of K_v1.3, voltage-gated K⁺ channel.

Selective inhibitor of Kv1.3, voltage-gated K+ channel. PAP-1 (EC₅₀=2 nM) potently inhibits human T effector memory cell proliferation and delayed hypersensitivity. Effective orally or intraperitoneally. 5-(4-Phenoxybutoxy)psoralen has 23-fold selectivity for Kv1.3 over Kv1.5, and 33-125-fold selectivity over other Kv1 family channels.

특징 및 장점

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

안전성 정보

• 픽토그램: GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H334
• 예방조치 성명서: P261 - P284 - P501
• Hazard Classifications: Resp. Sens. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Faceshields, Gloves