PZ0016

Dofetilide

≥98% (HPLC), powder, hERG channel blocker

• 동의어(들): N-[4-[2-[Methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl]amino]ethyl]phenyl]methanesulfonamide, UK-68798
• 실험식(Hill 표기법): C₁₉H₂₇N₃O₅S₂
• CAS Number: 115256-11-6
• Molecular Weight: 441.56
• MDL number: MFCD00869707
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329823685
• NACRES: NA.77

속성

• Product Name: Dofetilide, ≥98% (HPLC)
• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to off-white
• solubility: DMSO: >20 mg/mL
• 저장 온도: room temp
• SMILES string: CN(CCOc1ccc(NS(C)(=O)=O)cc1)CCc2ccc(NS(C)(=O)=O)cc2
• InChI: 1S/C19H27N3O5S2/c1-22(13-12-16-4-6-17(7-5-16)20-28(2,23)24)14-15-27-19-10-8-18(9-11-19)21-29(3,25)26/h4-11,20-21H,12-15H2,1-3H3
• InChI key: IXTMWRCNAAVVAI-UHFFFAOYSA-N
• 유전자 정보: human ... KCNH2(3757)

설명

생화학적/생리학적 작용

Dofetilide is a Class III antiarrhythmic and hERG channel blocker. Dofetilide selectively blocks the rapid component of the delayed rectifier outward potassium current (IKr).

특징 및 장점

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

안전성 정보

• 픽토그램: GHS08,GHS09
• 신호어: Danger
• 유해 및 위험 성명서: H360,H373,H411
• 예방조치 성명서: P202 - P260 - P273 - P280 - P308 + P313 - P391
• Hazard Classifications: Aquatic Chronic 2 - Repr. 1B - STOT RE 2
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: nwg
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable