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PZ0213

Sigma-Aldrich

PF-04418948

≥98% (HPLC)

동의어(들):

1-(4-Fluorobenzoyl)-3-[[(6-methoxy-2-naphthalenyl)oxy]methyl]-3-azetidinecarboxylic acid

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크기 선택

100 MG
143,00 $
1 G
262,00 $
5 G
743,00 $

143,00 $


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크기 선택

보기 변경
100 MG
143,00 $
1 G
262,00 $
5 G
743,00 $

About This Item

실험식(Hill 표기법):
C23H20FNO5
CAS Number:
Molecular Weight:
409.41
UNSPSC 코드:
12352200
NACRES:
NA.77

143,00 $


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기술 서비스
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도움 문의

Quality Level

분석

≥98% (HPLC)

양식

powder

색상

white to beige

solubility

DMSO: 20 mg/mL, clear

저장 온도

room temp

SMILES string

Fc1ccc(cc1)C(=O)N2CC(C2)(COc3cc4c(cc(cc4)OC)cc3)C(=O)O

InChI

1S/C23H20FNO5/c1-29-19-8-4-17-11-20(9-5-16(17)10-19)30-14-23(22(27)28)12-25(13-23)21(26)15-2-6-18(24)7-3-15/h2-11H,12-14H2,1H3,(H,27,28)

InChI key

LWJGMYMNSNVCEM-UHFFFAOYSA-N

유사한 품목 비교

전체 비교 보기

차이점 표시

1 of 4

이 품목
364622456292364630
isotopic purity

98 atom % D

isotopic purity

98 atom % D

isotopic purity

98 atom % D

isotopic purity

98 atom % D

mass shift

M+10

mass shift

M+10

mass shift

M+10

mass shift

M+14

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

form

solid

form

solid

form

solid

form

solid

mp

210-215 °C (lit.)

mp

98-100 °C (lit.)

mp

110-113 °C (lit.)

mp

212-213 °C (lit.)

bp

340 °C (lit.)

bp

340 °C (lit.)

bp

384 °C (lit.)

bp

-

애플리케이션

PF-04418948 has been used in TG (trigeminal ganglion) explant culture.[1]

생화학적/생리학적 작용

PF-04418948 is a PGE2 Receptor (EP2) specific antagonist (IC50 = 16 nM) with greater than 2000-fold selectivity over other EP subtypes. PF-04418948 inhibits EP2 activity in smooth muscle preps from human, dog and mouse.
PF-04418948 is a PGE2 Receptor (EP2) specific antagonist.
PF-04418948 represses the formation of colorectal tumor.[2]

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Katharina Neudorfer et al.
Diagnostic microbiology and infectious disease, 90(1), 58-63 (2017-12-03)
We tested the in vitro activity of dalbavancin, vancomycin and daptomycin against 83 enterococcal isolates in planktonic and biofilm states. The MIC90 for vancomycin-susceptible Enterococcus faecalis was 0.125 and 4μg/mL for dalbavancin and daptomycin, respectively. For vancomycin-resistant Enterococcus faecium, the
Helio S Sader et al.
Antimicrobial agents and chemotherapy, 62(3) (2017-12-22)
Dalbavancin activity was assessed against a large collection of Staphylococcus aureus isolates (n = 59,903), including isolates with decreased susceptibility to vancomycin (MIC, ≥2 mg/liter; n = 1,141), daptomycin (MIC, ≥2 mg/liter; n = 48), telavancin (MIC, ≥0.12 mg/liter; n
Zongru Guo
Acta pharmaceutica Sinica. B, 7(2), 119-136 (2017-03-18)
Drug innovation is characterized by painstaking molecular-level syntheses and modifications as the basic components of research and development. Similarly, natural products are chemically tailored and modified based upon their structural and biological properties. To some extent, the modification of natural
Michael A Pfaller et al.
International journal of antimicrobial agents, 51(4), 608-611 (2017-12-27)
Osteomyelitis is a difficult-to-treat infection that regularly involves prolonged use of systemic antibiotics. Dalbavancin has demonstrated activity against Gram-positive isolates, and has been considered as a candidate for the treatment of osteomyelitis in adults and children. This study evaluated the
Valentin Al Jalali et al.
Clinical pharmacokinetics, 57(7), 797-816 (2018-01-15)
Telavancin was discovered by modifying the chemical structure of vancomycin and belongs to the group of lipoglycopeptides. It employs its antimicrobial potential through two distinct mechanisms of action: inhibition of bacterial cell wall synthesis and induction of bacterial membrane depolarization

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