PZ0213
PF-04418948
≥98% (HPLC)
동의어(들):
1-(4-Fluorobenzoyl)-3-[[(6-methoxy-2-naphthalenyl)oxy]methyl]-3-azetidinecarboxylic acid
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100 MG
143,00 $
1 G
262,00 $
5 G
743,00 $
About This Item
실험식(Hill 표기법):
C23H20FNO5
CAS Number:
Molecular Weight:
409.41
UNSPSC 코드:
12352200
NACRES:
NA.77
추천 제품
Quality Level
분석
≥98% (HPLC)
양식
powder
색상
white to beige
solubility
DMSO: 20 mg/mL, clear
저장 온도
room temp
SMILES string
Fc1ccc(cc1)C(=O)N2CC(C2)(COc3cc4c(cc(cc4)OC)cc3)C(=O)O
InChI
1S/C23H20FNO5/c1-29-19-8-4-17-11-20(9-5-16(17)10-19)30-14-23(22(27)28)12-25(13-23)21(26)15-2-6-18(24)7-3-15/h2-11H,12-14H2,1H3,(H,27,28)
InChI key
LWJGMYMNSNVCEM-UHFFFAOYSA-N
1 of 4
이 품목 | 364622 | 456292 | 364630 |
---|---|---|---|
isotopic purity 98 atom % D | isotopic purity 98 atom % D | isotopic purity 98 atom % D | isotopic purity 98 atom % D |
mass shift M+10 | mass shift M+10 | mass shift M+10 | mass shift M+14 |
Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
form solid | form solid | form solid | form solid |
mp 210-215 °C (lit.) | mp 98-100 °C (lit.) | mp 110-113 °C (lit.) | mp 212-213 °C (lit.) |
bp 340 °C (lit.) | bp 340 °C (lit.) | bp 384 °C (lit.) | bp - |
애플리케이션
PF-04418948 has been used in TG (trigeminal ganglion) explant culture.[1]
생화학적/생리학적 작용
PF-04418948 is a PGE2 Receptor (EP2) specific antagonist (IC50 = 16 nM) with greater than 2000-fold selectivity over other EP subtypes. PF-04418948 inhibits EP2 activity in smooth muscle preps from human, dog and mouse.
PF-04418948 is a PGE2 Receptor (EP2) specific antagonist.
PF-04418948 represses the formation of colorectal tumor.[2]
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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이미 열람한 고객
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Diagnostic microbiology and infectious disease, 90(1), 58-63 (2017-12-03)
We tested the in vitro activity of dalbavancin, vancomycin and daptomycin against 83 enterococcal isolates in planktonic and biofilm states. The MIC90 for vancomycin-susceptible Enterococcus faecalis was 0.125 and 4μg/mL for dalbavancin and daptomycin, respectively. For vancomycin-resistant Enterococcus faecium, the
Helio S Sader et al.
Antimicrobial agents and chemotherapy, 62(3) (2017-12-22)
Dalbavancin activity was assessed against a large collection of Staphylococcus aureus isolates (n = 59,903), including isolates with decreased susceptibility to vancomycin (MIC, ≥2 mg/liter; n = 1,141), daptomycin (MIC, ≥2 mg/liter; n = 48), telavancin (MIC, ≥0.12 mg/liter; n
Zongru Guo
Acta pharmaceutica Sinica. B, 7(2), 119-136 (2017-03-18)
Drug innovation is characterized by painstaking molecular-level syntheses and modifications as the basic components of research and development. Similarly, natural products are chemically tailored and modified based upon their structural and biological properties. To some extent, the modification of natural
Michael A Pfaller et al.
International journal of antimicrobial agents, 51(4), 608-611 (2017-12-27)
Osteomyelitis is a difficult-to-treat infection that regularly involves prolonged use of systemic antibiotics. Dalbavancin has demonstrated activity against Gram-positive isolates, and has been considered as a candidate for the treatment of osteomyelitis in adults and children. This study evaluated the
Valentin Al Jalali et al.
Clinical pharmacokinetics, 57(7), 797-816 (2018-01-15)
Telavancin was discovered by modifying the chemical structure of vancomycin and belongs to the group of lipoglycopeptides. It employs its antimicrobial potential through two distinct mechanisms of action: inhibition of bacterial cell wall synthesis and induction of bacterial membrane depolarization
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