PZ0347

CP-424,174

≥98% (HPLC)

• 동의어(들): CP 424174, CP-424174, CP424174, N-[[[4-Chloro-2,6-bis(1-methylethyl)phenyl]amino]carbonyl]-3-(1-hydroxy-1-methylethyl)-benzenesulfonamide
• 실험식(Hill 표기법): C₂₂H₂₉ClN₂O₄S
• CAS Number: 210825-31-3
• Molecular Weight: 452.99
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 20 mg/mL, clear
• 저장 온도: room temp
• SMILES string: CC(O)(C)C1=CC(S(=O)(NC(NC2=C(C(C)C)C=C(Cl)C=C2C(C)C)=O)=O)=CC=C1
• InChI: 1S/C22H29ClN2O4S/c1-13(2)18-11-16(23)12-19(14(3)4)20(18)24-21(26)25-30(28,29)17-9-7-8-15(10-17)22(5,6)27/h7-14,27H,1-6H3,(H2,24,25,26)
• InChI key: YRSBLSHMKVQWHP-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

CP-424,174 is a cytokine release inhibitory drugs (CRID) that inhibits the post-translational processing and secretion of IL-1b in response to LPS and ATP in human monocytes. It is quite possible that similarly to CP-456,773 (termed CRID3), CP-424,174 inhibits both NLRP3 and AIM2 inflammasomes by preventing ASC oligomerisation.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable