S0439

SUMO-1 human

≥95% (SDS-PAGE), recombinant, expressed in E. coli (GST-tagged)

• 동의어(들): Sentrin-1
• MDL number: MFCD03458656
• UNSPSC 코드: 12352202
• NACRES: NA.32

속성

• 재조합: expressed in E. coli (GST-tagged)
• Quality Level: 200
• 분석: ≥95% (SDS-PAGE)
• 분자량: 38.5 kDa
• UniProt 수납 번호: P63165
• 배송 상태: dry ice
• 저장 온도: −70°C
• 유전자 정보: human ... SUMO1(7341)

설명

일반 설명

Small ubiquitin-like modifier 1 (SUMO-1), a protein, is one of the 5 SUMO paralogs expressed in mammalian cells with a low but significant homology with ubiquitin. This SUMO-1-GST fusion protein is produced from a DNA sequence corresponding to human SUMO-1 fused to a glutathione S-transferase (GST)-tag and is expressed in E. coli cells.

애플리케이션

SUMO-1 human has been used in pre-absorption for negative immunostaining to confirm the specificity of the small ubiquitin like modifier 1 (SUMO-1) antibody.

생화학적/생리학적 작용

Conjugated to a variety of proteins by UbcH9, including RanGAP1, IκBα, and PML without the requirement of an equivalent E3 ubiquitin ligase.

Small ubiquitin-like modifier 1 (SUMO-1) plays a key role in modulating survival, migration, and signal transduction in some cell lines. It can prevent in vitro migration and invasion of RA fibroblast-like synoviocytes (FLSs). Higher expression of SUMO-1 may result in joint destruction in rheumatoid arthritis (RA).

물리적 형태

Solution in 50 mM HEPES, pH 8.0, 150 mM NaCl and 1 mM DTT.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)