S0758

Sulfaphenazole

≥98%

• 동의어(들): 4-Amino-N-(1-phenyl-1H-pyrazol-5-yl)benzenesulfonamide
• 실험식(Hill 표기법): C₁₅H₁₄N₄O₂S
• CAS Number: 526-08-9
• Molecular Weight: 314.36
• EC Number: 208-384-3
• MDL number: MFCD00057226
• UNSPSC 코드: 12352204
• PubChem Substance ID: 24278198
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98%
• 양식: powder
• solubility: ethanol: 25 mg/mL, clear, colorless to yellow
• 저장 온도: 2-8°C
• SMILES string: Nc1ccc(cc1)S(=O)(=O)Nc2ccnn2-c3ccccc3
• InChI: 1S/C15H14N4O2S/c16-12-6-8-14(9-7-12)22(20,21)18-15-10-11-17-19(15)13-4-2-1-3-5-13/h1-11,18H,16H2
• InChI key: QWCJHSGMANYXCW-UHFFFAOYSA-N
• 유전자 정보: human ... CYP2C18(1562), CYP2C19(1557), CYP2C9(1559)

설명

애플리케이션

Sulfaphenazole has been used as a positive control to inhibit cytochrome P450 2C9 (cyp2c9) to quantify Rhodiola rosea inhibition. It has also been used as cytochrome P450 2C9 (cyp2c9) inhibitor in endothelial cells and microsomal preparations.

생화학적/생리학적 작용

Antibacterial. Specific inhibitor of CYP2C9. Blocks pro-inflammatory and atherogenic effects of linoleic acid (increase in oxidative stress and activation of AP-1) mediated by CYP2C9. Specific inhibitor of CYP2C9. Blocks pro-inflammatory and atherogenic effects of linoleic acid (increase in oxidative stress and activation of AP-1) mediated by CYP2C9. Inhibits bradykinin-induced tPA release.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)