S1515

Anti-Spectrin antibody produced in rabbit

whole antiserum

• 동의어(들): Anti-EL2, Anti-HPP, Anti-HS3, Anti-SPH3, Anti-SPTA
• MDL number: MFCD00164739
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 200
• 결합: unconjugated
• 항체 형태: whole antiserum
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 포함: 15 mM sodium azide
• 종 반응성: human
• 기술: western blot: 1:400
• UniProt 수납 번호: P02549
• 배송 상태: dry ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... SPTA1(6708), SPTB(6710), SPTBN1(6711), SPTBN2(6712), SPTBN4(57731), SPTBN5(51332)

설명

일반 설명

Spectrin is a multifunctional protein that has lipid-binding sites within CH (calponin-homology) tandem domains, a PH (pleckstrin homology) domain and triple helical segments. It is located on chromosome 1q23.1.

Spectrin is the major cytoskeletal component in erythrocytes. It is composed of two types of polypeptides known as α and β with molecular weights of 240 and 220 kDa, respectively. The α- and β-chains form heterotetramers which are linked end-to-end via oligomeric actin and band 4.1 protein.

특이성

The antibody reacts specifically with the α and β chains of human erythrocyte spectrin.

면역원

spectrin from freshly prepared human erythrocyte ghosts.

애플리케이션

Anti-Spectrin antibody has been used in western blotting immunofluorescence and immunostaining.

생화학적/생리학적 작용

Spectrins modulates the cell morphology and mechanical properties. Spectrins also participates in the cell cycle by controlling the upregulation of membrane receptors. α- and β spectrins are essential for the development of nervous system.

The spectrin-based membrane skeleton is essential to provide mechanical stability and membrane integrity. It is also responsible for protein organization, trafficking and resilience of erythrocytes.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: nwg
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable