S1688

SR 57227A

solid

• 동의어(들): 4-amino-1-(6-chloro-2-pyridyl)-piperidine hydrochloride
• 실험식(Hill 표기법): C₁₀H₁₄ClN₃ · HCl
• CAS Number: 77145-61-0
• Molecular Weight: 248.15
• MDL number: MFCD01756430
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24278109
• NACRES: NA.77

속성

• 양식: solid
• Quality Level: 100
• 색상: white
• solubility: H₂O: soluble 9 mg/mL
• SMILES string: Cl.NC1CCN(CC1)c2cccc(Cl)n2
• InChI: 1S/C10H14ClN3.ClH/c11-9-2-1-3-10(13-9)14-6-4-8(12)5-7-14;/h1-3,8H,4-7,12H2;1H
• InChI key: FUMINTAAUJUVMP-UHFFFAOYSA-N
• 유전자 정보: human ... HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242)

설명

애플리케이션

SR 57227A may be used in 5-HT₃-mediated cell signaling studies.

생화학적/생리학적 작용

Potent and selective 5-HT₃ serotonin receptor agonist.

SR 57227A is a highly selective of central and peripheral 5-HT₃ receptors and an inhibitor of NMDA receptor-mediated responses in rat cortical pyramidal cells. It exhibits anti-depressant like effects in rats and decreased isolation-induced aggressive behavior.

안전성 정보

• 픽토그램: GHS06
• 신호어: Danger
• 유해 및 위험 성명서: H301,H315,H319,H335
• 예방조치 성명서: P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges